Birth characteristics and female sex hormone concentrations during adolescence: Results from the Dietary Intervention Study in Children

Elizabeth H. Ruder, Terryl Johnson Hartman, Michael J. Rovine, Joanne F. Dorgan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background Birth characteristics and adult hormone concentrations influence breast cancer risk, but little is known about the influence of birth characteristics on hormone concentrations, particularly during adolescence. Methods We evaluated the association of birth characteristics (birth weight, birth length, and gestational age) with serum sex hormone concentrations during late childhood and adolescence in 278 female participants of the Dietary Intervention Study in Children. Repeated measures analysis of variance models were used to assess the relationships of birth characteristics and serum estrogens and androgens at five different time points over a mean period of 7 years. Results In analyses that did not take into account time from blood draw until menarche, birth weight was inversely associated with pre-menarche concentrations of estradiol, estrone sulfate, androstenedione, testosterone, and dehydroepiandrosterone sulfate (DHEAS). In the postmenarche analyses, birth weight was not significantly associated with concentration of any of the hormones under investigation. Birth length and gestational age were not associated with hormone concentrations before or after menarche. Conclusion Birth weight is inversely associated with sex hormone concentrations before menarche in the model unadjusted for time from blood draw until menarche. Impact The in utero environment has long-term influences on the hormonal milieu, which could potentially contribute to breast cancer risk.

Original languageEnglish (US)
Pages (from-to)611-621
Number of pages11
JournalCancer Causes and Control
Volume22
Issue number4
DOIs
StatePublished - Apr 1 2011

Fingerprint

Gonadal Steroid Hormones
Menarche
Parturition
Birth Weight
Hormones
Gestational Age
Breast Neoplasms
Dehydroepiandrosterone Sulfate
Androstenedione
Serum
Androgens
Testosterone
Analysis of Variance
Estrogens

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ruder, Elizabeth H. ; Hartman, Terryl Johnson ; Rovine, Michael J. ; Dorgan, Joanne F. / Birth characteristics and female sex hormone concentrations during adolescence : Results from the Dietary Intervention Study in Children. In: Cancer Causes and Control. 2011 ; Vol. 22, No. 4. pp. 611-621.
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Birth characteristics and female sex hormone concentrations during adolescence : Results from the Dietary Intervention Study in Children. / Ruder, Elizabeth H.; Hartman, Terryl Johnson; Rovine, Michael J.; Dorgan, Joanne F.

In: Cancer Causes and Control, Vol. 22, No. 4, 01.04.2011, p. 611-621.

Research output: Contribution to journalArticle

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