Bismuth Subsalicylate in the Treatment of Chronic Diarrhea of Childhood

Joyce D. Gryboski, A. Craig Hillemeier, Bruce Grill, Samuel Kocoshis

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Twenty‐nine infants and children, age 2–70 months with chronic diarrhea, were admitted to a double‐blind, parallel clinical trial. The subjects were randomly assigned to receive either a bismuth subsalicylate liquid or a placebo liquid formulation. Treatment was given for 7 days with dosage varied according to age. Analysis of the results showed that the subjects in the bismuth subsalicylate‐treated group gained significantly more weight (p < 0.05), had significantly fewer (p < 0.01) and firmer (p < 0.01) stools with less water content (p< 0.01) during the course of the study than did the placebo‐treated group. Response to treatment, as graded by nursing staff, family, and physicians was moderate to excellent in 86% of the treated group while none of the placebo group received such a rating (p <0.01). No differences were noted between stool weights or bile acid excretion.

Original languageEnglish (US)
Pages (from-to)871-876
Number of pages6
JournalThe American journal of gastroenterology
Volume80
Issue number11
DOIs
StatePublished - Nov 1985

Fingerprint

Diarrhea
Placebos
Weights and Measures
Bismuth
Nursing Staff
Family Physicians
Bile Acids and Salts
Clinical Trials
Water
Therapeutics
bismuth subsalicylate

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Gryboski, Joyce D. ; Hillemeier, A. Craig ; Grill, Bruce ; Kocoshis, Samuel. / Bismuth Subsalicylate in the Treatment of Chronic Diarrhea of Childhood. In: The American journal of gastroenterology. 1985 ; Vol. 80, No. 11. pp. 871-876.
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Bismuth Subsalicylate in the Treatment of Chronic Diarrhea of Childhood. / Gryboski, Joyce D.; Hillemeier, A. Craig; Grill, Bruce; Kocoshis, Samuel.

In: The American journal of gastroenterology, Vol. 80, No. 11, 11.1985, p. 871-876.

Research output: Contribution to journalArticle

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