Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug

X. Chelsea Chen, Hee Jeung Oh, Jay F. Yu, Jeffrey K. Yang, Nikos Petzetakis, Anand S. Patel, Steven W. Hetts, Nitash P. Balsara

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We introduce the use of block copolymer membranes for an emerging application, "drug capture". The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the efficacy of chemotherapy-based cancer treatment. We show that block copolymer membranes consisting of functional sulfonated polystyrene end blocks and a structural polyethylene middle block (S-SES) are capable of capturing doxorubicin, a chemotherapy drug. We focus on the relationship between morphology of the membrane in the ChemoFilter device and efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray scattering and cryogenic scanning transmission electron microscopy, we discovered that rapid doxorubicin capture is associated with the presence of water-rich channels in the lamellar-forming S-SES membranes in aqueous environment.

Original languageEnglish (US)
Pages (from-to)936-941
Number of pages6
JournalACS Macro Letters
Volume5
Issue number8
DOIs
StatePublished - Aug 16 2016

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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