Blood pressure and leg deoxygenation are exaggerated during treadmill walking in patients with peripheral artery disease

Amanda J. Miller, J. Carter Luck, Danielle Jin Kwang Kim, Urs A. Leuenberger, David N. Proctor, Lawrence I. Sinoway, Matthew D. Muller

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to investigate blood pressure (BP) and leg skeletal muscle oxygen saturation (SmO2) during treadmill walking in patients with peripheral artery disease (PAD) and healthy subjects. Eight PAD patients (66 ± 8 yr, 1 woman) and eight healthy subjects (65 ± 7 yr, 1 woman) walked on a treadmill at 2 mph (0.89 m/s). The incline increased by 2% every 2 min, from 0 to 15% or until maximal discomfort. BP was measured every 2 min with an auscultatory cuff. Heart rate (HR) was recorded continuously with an ECG. SmO2 in the gastrocnemius muscle was measured on each leg using near-infrared spectroscopy. The change in systolic BP from seated to peak walking time (PWT) was greater in PAD (healthy: 23 ± 9 vs. PAD: 44 ± 19 mmHg, P = 0.007). HR was greater in PAD patients compared with controls at PWT (P = 0.011). The reduction in SmO2 (PWT - seated) was greater in PAD (healthy: 15 ± 12 vs. PAD: 49 ± 5%, P < 0.001) in the most affected leg and in the least affected leg (healthy: 12 = 11 vs. PAD: 32- 18%, P = 0.003). PAD patients have an exaggerated decline in leg SmO2 during walking compared with healthy subjects, which may elicit the exaggerated rise in BP and HR during walking in PAD. NEW & NOTEWORTHY This is the first study to simultaneously measure skeletal muscle oxygen saturation and blood pressure (BP) during treadmill exercise in patients with peripheral arterial disease. We found that BP and leg deoxygenation responses to slow-paced, graded treadmill walking are greater in patients with peripheral arterial disease compared with healthy subjects. These data may help explain the high cardiovascular risk in patients with peripheral arterial disease.

LanguageEnglish (US)
Pages1160-1165
Number of pages6
JournalJournal of applied physiology
Volume123
Issue number5
DOIs
StatePublished - Nov 1 2017

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Peripheral Arterial Disease
Walking
Leg
Blood Pressure
Healthy Volunteers
Skeletal Muscle
Heart Rate
Oxygen
Near-Infrared Spectroscopy
Electrocardiography

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

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title = "Blood pressure and leg deoxygenation are exaggerated during treadmill walking in patients with peripheral artery disease",
abstract = "The purpose of this study was to investigate blood pressure (BP) and leg skeletal muscle oxygen saturation (SmO2) during treadmill walking in patients with peripheral artery disease (PAD) and healthy subjects. Eight PAD patients (66 ± 8 yr, 1 woman) and eight healthy subjects (65 ± 7 yr, 1 woman) walked on a treadmill at 2 mph (0.89 m/s). The incline increased by 2{\%} every 2 min, from 0 to 15{\%} or until maximal discomfort. BP was measured every 2 min with an auscultatory cuff. Heart rate (HR) was recorded continuously with an ECG. SmO2 in the gastrocnemius muscle was measured on each leg using near-infrared spectroscopy. The change in systolic BP from seated to peak walking time (PWT) was greater in PAD (healthy: 23 ± 9 vs. PAD: 44 ± 19 mmHg, P = 0.007). HR was greater in PAD patients compared with controls at PWT (P = 0.011). The reduction in SmO2 (PWT - seated) was greater in PAD (healthy: 15 ± 12 vs. PAD: 49 ± 5{\%}, P < 0.001) in the most affected leg and in the least affected leg (healthy: 12 = 11 vs. PAD: 32- 18{\%}, P = 0.003). PAD patients have an exaggerated decline in leg SmO2 during walking compared with healthy subjects, which may elicit the exaggerated rise in BP and HR during walking in PAD. NEW & NOTEWORTHY This is the first study to simultaneously measure skeletal muscle oxygen saturation and blood pressure (BP) during treadmill exercise in patients with peripheral arterial disease. We found that BP and leg deoxygenation responses to slow-paced, graded treadmill walking are greater in patients with peripheral arterial disease compared with healthy subjects. These data may help explain the high cardiovascular risk in patients with peripheral arterial disease.",
author = "Miller, {Amanda J.} and Luck, {J. Carter} and Kim, {Danielle Jin Kwang} and Leuenberger, {Urs A.} and Proctor, {David N.} and Sinoway, {Lawrence I.} and Muller, {Matthew D.}",
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Blood pressure and leg deoxygenation are exaggerated during treadmill walking in patients with peripheral artery disease. / Miller, Amanda J.; Luck, J. Carter; Kim, Danielle Jin Kwang; Leuenberger, Urs A.; Proctor, David N.; Sinoway, Lawrence I.; Muller, Matthew D.

In: Journal of applied physiology, Vol. 123, No. 5, 01.11.2017, p. 1160-1165.

Research output: Contribution to journalArticle

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N2 - The purpose of this study was to investigate blood pressure (BP) and leg skeletal muscle oxygen saturation (SmO2) during treadmill walking in patients with peripheral artery disease (PAD) and healthy subjects. Eight PAD patients (66 ± 8 yr, 1 woman) and eight healthy subjects (65 ± 7 yr, 1 woman) walked on a treadmill at 2 mph (0.89 m/s). The incline increased by 2% every 2 min, from 0 to 15% or until maximal discomfort. BP was measured every 2 min with an auscultatory cuff. Heart rate (HR) was recorded continuously with an ECG. SmO2 in the gastrocnemius muscle was measured on each leg using near-infrared spectroscopy. The change in systolic BP from seated to peak walking time (PWT) was greater in PAD (healthy: 23 ± 9 vs. PAD: 44 ± 19 mmHg, P = 0.007). HR was greater in PAD patients compared with controls at PWT (P = 0.011). The reduction in SmO2 (PWT - seated) was greater in PAD (healthy: 15 ± 12 vs. PAD: 49 ± 5%, P < 0.001) in the most affected leg and in the least affected leg (healthy: 12 = 11 vs. PAD: 32- 18%, P = 0.003). PAD patients have an exaggerated decline in leg SmO2 during walking compared with healthy subjects, which may elicit the exaggerated rise in BP and HR during walking in PAD. NEW & NOTEWORTHY This is the first study to simultaneously measure skeletal muscle oxygen saturation and blood pressure (BP) during treadmill exercise in patients with peripheral arterial disease. We found that BP and leg deoxygenation responses to slow-paced, graded treadmill walking are greater in patients with peripheral arterial disease compared with healthy subjects. These data may help explain the high cardiovascular risk in patients with peripheral arterial disease.

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