Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Mia M. Gaudet, Andrew F. Olshan, Shu Chun Chuang, Julien Berthiller, Zuo Feng Zhang, Jolanta Lissowska, David Zaridze, Deborah M. Winn, Qingyi Wei, Renato Talamini, Neolilia Szeszenia-Dabrowska, Erich M. Sturgis, Stephen M. Schwartz, Peter Rudnai, Jose Eluf-Neto, Joshua Muscat, Hal Morgenstern, Ana Menezes, Elena Matos, Alexandru BucurFabio Levi, Philip Lazarus, Carlo La Vecchia, Sergio Koifman, Karl Kelsey, Rolando Herrero, Richard B. Hayes, Silva Franceschi, Victor Wunsch-Filho, Leticia Fernandez, Eleonora Fabianova, Alexander W. Daudt, Luigino Dal Maso, Maria Paula Curado, Chu Chen, Xavier Castellsague, Simone Benhamou, Paolo Boffetta, Paul Brennan, Mia Hashibe

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Background: Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding from the effects of alcohol and tobacco use or by other sources of biases. Methods: We pooled data from 17 case-control studies including 12 716 cases and the 17 438 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between body mass index (BMI) at different ages and HNC risk, adjusted for age, sex, centre, race, education, tobacco smoking and alcohol consumption. Results: Adjusted ORs (95% CIs) were elevated for people with BMI at reference (date of diagnosis for cases and date of selection for controls) ≤18.5 kg/m2 (2.13, 1.75-2.58) and reduced for BMI >25.0-30.0 kg/m2 (0.52, 0.44-0.60) and BMI ≥30 kg/m2 (0.43, 0.33-0.57), compared with BMI >18.5-25.0 kg/m2. These associations did not differ by age, sex, tumour site or control source. Although the increased risk among people with BMI ≤18.5 kg/m2 was not modified by tobacco smoking or alcohol drinking, the inverse association for people with BMI > 25 kg/m2 was present only in smokers and drinkers. Conclusions: In our large pooled analysis, leanness was associated with increased HNC risk regardless of smoking and drinking status, although reverse causality cannot be excluded. The reduced risk among overweight or obese people may indicate body size is a modifier of the risk associated with smoking and drinking. Further clarification may be provided by analyses of prospective cohort and mechanistic studies.

Original languageEnglish (US)
Article numberdyp380
Pages (from-to)1091-1102
Number of pages12
JournalInternational journal of epidemiology
Volume39
Issue number4
DOIs
StatePublished - Feb 1 2010

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Head and Neck Neoplasms
Case-Control Studies
Epidemiology
Body Mass Index
Smoking
Tobacco Use
Alcohol Drinking
Drinking
Odds Ratio
Confidence Intervals
Thinness
Body Size
Causality
Cohort Studies
Alcohols
Education
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Gaudet, Mia M. ; Olshan, Andrew F. ; Chuang, Shu Chun ; Berthiller, Julien ; Zhang, Zuo Feng ; Lissowska, Jolanta ; Zaridze, David ; Winn, Deborah M. ; Wei, Qingyi ; Talamini, Renato ; Szeszenia-Dabrowska, Neolilia ; Sturgis, Erich M. ; Schwartz, Stephen M. ; Rudnai, Peter ; Eluf-Neto, Jose ; Muscat, Joshua ; Morgenstern, Hal ; Menezes, Ana ; Matos, Elena ; Bucur, Alexandru ; Levi, Fabio ; Lazarus, Philip ; La Vecchia, Carlo ; Koifman, Sergio ; Kelsey, Karl ; Herrero, Rolando ; Hayes, Richard B. ; Franceschi, Silva ; Wunsch-Filho, Victor ; Fernandez, Leticia ; Fabianova, Eleonora ; Daudt, Alexander W. ; Dal Maso, Luigino ; Curado, Maria Paula ; Chen, Chu ; Castellsague, Xavier ; Benhamou, Simone ; Boffetta, Paolo ; Brennan, Paul ; Hashibe, Mia. / Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. In: International journal of epidemiology. 2010 ; Vol. 39, No. 4. pp. 1091-1102.
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abstract = "Background: Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding from the effects of alcohol and tobacco use or by other sources of biases. Methods: We pooled data from 17 case-control studies including 12 716 cases and the 17 438 controls. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) were estimated for associations between body mass index (BMI) at different ages and HNC risk, adjusted for age, sex, centre, race, education, tobacco smoking and alcohol consumption. Results: Adjusted ORs (95{\%} CIs) were elevated for people with BMI at reference (date of diagnosis for cases and date of selection for controls) ≤18.5 kg/m2 (2.13, 1.75-2.58) and reduced for BMI >25.0-30.0 kg/m2 (0.52, 0.44-0.60) and BMI ≥30 kg/m2 (0.43, 0.33-0.57), compared with BMI >18.5-25.0 kg/m2. These associations did not differ by age, sex, tumour site or control source. Although the increased risk among people with BMI ≤18.5 kg/m2 was not modified by tobacco smoking or alcohol drinking, the inverse association for people with BMI > 25 kg/m2 was present only in smokers and drinkers. Conclusions: In our large pooled analysis, leanness was associated with increased HNC risk regardless of smoking and drinking status, although reverse causality cannot be excluded. The reduced risk among overweight or obese people may indicate body size is a modifier of the risk associated with smoking and drinking. Further clarification may be provided by analyses of prospective cohort and mechanistic studies.",
author = "Gaudet, {Mia M.} and Olshan, {Andrew F.} and Chuang, {Shu Chun} and Julien Berthiller and Zhang, {Zuo Feng} and Jolanta Lissowska and David Zaridze and Winn, {Deborah M.} and Qingyi Wei and Renato Talamini and Neolilia Szeszenia-Dabrowska and Sturgis, {Erich M.} and Schwartz, {Stephen M.} and Peter Rudnai and Jose Eluf-Neto and Joshua Muscat and Hal Morgenstern and Ana Menezes and Elena Matos and Alexandru Bucur and Fabio Levi and Philip Lazarus and {La Vecchia}, Carlo and Sergio Koifman and Karl Kelsey and Rolando Herrero and Hayes, {Richard B.} and Silva Franceschi and Victor Wunsch-Filho and Leticia Fernandez and Eleonora Fabianova and Daudt, {Alexander W.} and {Dal Maso}, Luigino and Curado, {Maria Paula} and Chu Chen and Xavier Castellsague and Simone Benhamou and Paolo Boffetta and Paul Brennan and Mia Hashibe",
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language = "English (US)",
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pages = "1091--1102",
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Gaudet, MM, Olshan, AF, Chuang, SC, Berthiller, J, Zhang, ZF, Lissowska, J, Zaridze, D, Winn, DM, Wei, Q, Talamini, R, Szeszenia-Dabrowska, N, Sturgis, EM, Schwartz, SM, Rudnai, P, Eluf-Neto, J, Muscat, J, Morgenstern, H, Menezes, A, Matos, E, Bucur, A, Levi, F, Lazarus, P, La Vecchia, C, Koifman, S, Kelsey, K, Herrero, R, Hayes, RB, Franceschi, S, Wunsch-Filho, V, Fernandez, L, Fabianova, E, Daudt, AW, Dal Maso, L, Curado, MP, Chen, C, Castellsague, X, Benhamou, S, Boffetta, P, Brennan, P & Hashibe, M 2010, 'Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium', International journal of epidemiology, vol. 39, no. 4, dyp380, pp. 1091-1102. https://doi.org/10.1093/ije/dyp380

Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. / Gaudet, Mia M.; Olshan, Andrew F.; Chuang, Shu Chun; Berthiller, Julien; Zhang, Zuo Feng; Lissowska, Jolanta; Zaridze, David; Winn, Deborah M.; Wei, Qingyi; Talamini, Renato; Szeszenia-Dabrowska, Neolilia; Sturgis, Erich M.; Schwartz, Stephen M.; Rudnai, Peter; Eluf-Neto, Jose; Muscat, Joshua; Morgenstern, Hal; Menezes, Ana; Matos, Elena; Bucur, Alexandru; Levi, Fabio; Lazarus, Philip; La Vecchia, Carlo; Koifman, Sergio; Kelsey, Karl; Herrero, Rolando; Hayes, Richard B.; Franceschi, Silva; Wunsch-Filho, Victor; Fernandez, Leticia; Fabianova, Eleonora; Daudt, Alexander W.; Dal Maso, Luigino; Curado, Maria Paula; Chen, Chu; Castellsague, Xavier; Benhamou, Simone; Boffetta, Paolo; Brennan, Paul; Hashibe, Mia.

In: International journal of epidemiology, Vol. 39, No. 4, dyp380, 01.02.2010, p. 1091-1102.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

AU - Gaudet, Mia M.

AU - Olshan, Andrew F.

AU - Chuang, Shu Chun

AU - Berthiller, Julien

AU - Zhang, Zuo Feng

AU - Lissowska, Jolanta

AU - Zaridze, David

AU - Winn, Deborah M.

AU - Wei, Qingyi

AU - Talamini, Renato

AU - Szeszenia-Dabrowska, Neolilia

AU - Sturgis, Erich M.

AU - Schwartz, Stephen M.

AU - Rudnai, Peter

AU - Eluf-Neto, Jose

AU - Muscat, Joshua

AU - Morgenstern, Hal

AU - Menezes, Ana

AU - Matos, Elena

AU - Bucur, Alexandru

AU - Levi, Fabio

AU - Lazarus, Philip

AU - La Vecchia, Carlo

AU - Koifman, Sergio

AU - Kelsey, Karl

AU - Herrero, Rolando

AU - Hayes, Richard B.

AU - Franceschi, Silva

AU - Wunsch-Filho, Victor

AU - Fernandez, Leticia

AU - Fabianova, Eleonora

AU - Daudt, Alexander W.

AU - Dal Maso, Luigino

AU - Curado, Maria Paula

AU - Chen, Chu

AU - Castellsague, Xavier

AU - Benhamou, Simone

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Hashibe, Mia

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Background: Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding from the effects of alcohol and tobacco use or by other sources of biases. Methods: We pooled data from 17 case-control studies including 12 716 cases and the 17 438 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between body mass index (BMI) at different ages and HNC risk, adjusted for age, sex, centre, race, education, tobacco smoking and alcohol consumption. Results: Adjusted ORs (95% CIs) were elevated for people with BMI at reference (date of diagnosis for cases and date of selection for controls) ≤18.5 kg/m2 (2.13, 1.75-2.58) and reduced for BMI >25.0-30.0 kg/m2 (0.52, 0.44-0.60) and BMI ≥30 kg/m2 (0.43, 0.33-0.57), compared with BMI >18.5-25.0 kg/m2. These associations did not differ by age, sex, tumour site or control source. Although the increased risk among people with BMI ≤18.5 kg/m2 was not modified by tobacco smoking or alcohol drinking, the inverse association for people with BMI > 25 kg/m2 was present only in smokers and drinkers. Conclusions: In our large pooled analysis, leanness was associated with increased HNC risk regardless of smoking and drinking status, although reverse causality cannot be excluded. The reduced risk among overweight or obese people may indicate body size is a modifier of the risk associated with smoking and drinking. Further clarification may be provided by analyses of prospective cohort and mechanistic studies.

AB - Background: Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding from the effects of alcohol and tobacco use or by other sources of biases. Methods: We pooled data from 17 case-control studies including 12 716 cases and the 17 438 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between body mass index (BMI) at different ages and HNC risk, adjusted for age, sex, centre, race, education, tobacco smoking and alcohol consumption. Results: Adjusted ORs (95% CIs) were elevated for people with BMI at reference (date of diagnosis for cases and date of selection for controls) ≤18.5 kg/m2 (2.13, 1.75-2.58) and reduced for BMI >25.0-30.0 kg/m2 (0.52, 0.44-0.60) and BMI ≥30 kg/m2 (0.43, 0.33-0.57), compared with BMI >18.5-25.0 kg/m2. These associations did not differ by age, sex, tumour site or control source. Although the increased risk among people with BMI ≤18.5 kg/m2 was not modified by tobacco smoking or alcohol drinking, the inverse association for people with BMI > 25 kg/m2 was present only in smokers and drinkers. Conclusions: In our large pooled analysis, leanness was associated with increased HNC risk regardless of smoking and drinking status, although reverse causality cannot be excluded. The reduced risk among overweight or obese people may indicate body size is a modifier of the risk associated with smoking and drinking. Further clarification may be provided by analyses of prospective cohort and mechanistic studies.

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U2 - 10.1093/ije/dyp380

DO - 10.1093/ije/dyp380

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C2 - 20123951

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JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

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