Body weight change of aged rats on fat option diets

M. Young, Rebecca L. Corwin

Research output: Contribution to journalArticle

Abstract

Variability in caloric intake may contribute to compromised nutritional sutus in the elderly, yet mechanisms regulating food intake and body weight in aged groups are poorly understood. This study was designed to determine if aging is associated with a decline in the ability to compensate for alterations in the caloric density of the diet in rats. 3 groups of male F344/BN rats were used:young (3 mo; n=21), middle-aged (MA; 22 mo; n=20), old (30 mo; n=22). After matching for body weight, half of the rats in each group were assigned to a chow-only (C) condition, and half to a limited access fat option (F) condition. All groups had 24-h access to chow (Rodent Diet 5001, PMI Feeds. Richmond, IN) and water. In addition to chow, during weeks 1 and 2 (Phase I) F rats had daily 2-h access to fat (Crisco, Proctor and Gamble, Cincinnati, OH), 3-h prior to lights out. During weeks 3 and 4 (Phase II) 2-h fat access was provided on M, W, F only. 24-h chow and Crisco intakes were measured daily and body weights biweekly. During Phase I, MA and old F rats consumed more calories (p<0.05) and gained more weight (p<0.01) when compared to controls, but not when compared to each other. In Phase II, 24-h food intake patterns differed between F and C rats in each age group, i.e., F rats overate on Crisco days (p<0.05), and undorate on non-Crisco days (p<0.05). Additionally, MA and old F rats lost more weight than controls (p<0.01), but when compared to each other, old F rats lost more weight than MA F rats (p<0.001). These results suggest that fluctuations in the availability of calorically dense foods may impair body weight regulation and contribute to compromised nutritional status in the elderly.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - Dec 1 1997

Fingerprint

Body Weight Changes
body weight changes
Nutrition
Rats
Fats
Diet
rats
lipids
diet
Body Weight
body weight
Weights and Measures
Inbred BN Rats
Eating
food intake
middle-aged adults
Weight control
Inbred F344 Rats
Energy Intake
Nutritional Status

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Young, M., & Corwin, R. L. (1997). Body weight change of aged rats on fat option diets. FASEB Journal, 11(3).
Young, M. ; Corwin, Rebecca L. / Body weight change of aged rats on fat option diets. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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Young, M & Corwin, RL 1997, 'Body weight change of aged rats on fat option diets', FASEB Journal, vol. 11, no. 3.

Body weight change of aged rats on fat option diets. / Young, M.; Corwin, Rebecca L.

In: FASEB Journal, Vol. 11, No. 3, 01.12.1997.

Research output: Contribution to journalArticle

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