Bolus pharmacokinetics: moving beyond mass-based dosing to guide drug administration

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Abstract

Despite the common approach of bolus drug dosing using a patient’s mass, a more tailored approach would be to use empirically derived pharmacokinetic models. Previously, this could only be possible though the use of computer simulation using programs which are rarely available in clinical practice. Through mathematical manipulations and approximations, a simplified set of equations is demonstrated that can identify a bolus dose required to achieve a specified target effect site concentration. The proposed solution is compared against simulations of a wide variety of pharmacokinetic models. This set of equations provides a near-identical solution to the simulation approach. A boundary condition is established to ensure the derived equations have an acceptable error. This approach may allow for more precise administration of medications with the use of point of care technology and potentially allows for pharmacokinetic dosing in artificial intelligence problems.

Original languageEnglish (US)
Pages (from-to)573-581
Number of pages9
JournalJournal of Pharmacokinetics and Pharmacodynamics
Volume47
Issue number6
DOIs
StatePublished - Dec 2020

All Science Journal Classification (ASJC) codes

  • Pharmacology

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