Bombesin suppresses feeding in rats [10]

J. Gibbs, D. J. Fauser, E. A. Rowe, Barbara Jean Rolls, E. T. Rolls, S. P. Maddison

Research output: Contribution to journalLetter

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Abstract

Bombesin (BBS) is a tetradecapeptide originally isolated from amphibian skin1. BBS-like irnmunoactivity is widely distributed in mammalian gut2-5, and plasma levels have been shown to rise sharply following feeding (ref. 6 and V. Erspamer, personal communication). The physiological actions of BBS are unknown. We have previously shown that the classic gut hormone cholecystokinin (CCK) is a powerful and specific suppressor of food intake7-9. Although CCK and BBS lack common amino acid sequences, they have certain common actions on gut viscera10,11. We have now shown that BBS also suppresses food intake, and we compare its action with that of CCK.

Original languageEnglish (US)
Pages (from-to)208-210
Number of pages3
JournalNature
Volume282
Issue number5735
DOIs
StatePublished - Dec 1 1979

All Science Journal Classification (ASJC) codes

  • General

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    Gibbs, J., Fauser, D. J., Rowe, E. A., Rolls, B. J., Rolls, E. T., & Maddison, S. P. (1979). Bombesin suppresses feeding in rats [10]. Nature, 282(5735), 208-210. https://doi.org/10.1038/282208a0