Abstract

Objective: To examine bone mineral density (BMD) and fat distribution in lean women with polycystic ovary syndrome (PCOS) compared with matched control women. Design: Controlled clinical study. Setting: An academic clinical research center. Patient(s): Twelve non-Hispanic white women with PCOS and a body mass index of <26 and 10 healthy control women matched for age, ethnicity, and weight. Intervention(s): Biometric measures, blood sample collection, and total body/regional bone density and fat analysis were performed. Main Outcome Measure(s): Serum levels of androgens, glucose, and insulin were measured. Bone density and fat distribution were measured by total body dual-energy x-ray absorptiometry. Result(s): Androgen levels were elevated significantly in the lean women with PCOS compared with the controls. There was no statistically significant difference in total body BMD between the two groups. A significant increase in BMD was noted in the left arm, right arm, and left ribs of the lean PCOS group. Evaluation of upper body BMD showed a significant correlation between testosterone levels and BMD. No statistically significant differences were noted in body fat distribution, although the lean PCOS group tended to have lower mean percentages of body fat. Conclusion(s): Lean women with PCOS have regional differences in BMD, with significantly increased BMD in the upper skeleton compared with control women.

Original languageEnglish (US)
Pages (from-to)21-25
Number of pages5
JournalFertility and sterility
Volume72
Issue number1
DOIs
StatePublished - Jul 1 1999

Fingerprint

Polycystic Ovary Syndrome
Body Composition
Bone Density
Fats
Androgens
Body Fat Distribution
Ribs
Skeleton
Testosterone
Adipose Tissue
Body Mass Index
X-Rays
Outcome Assessment (Health Care)
Insulin
Weights and Measures
Glucose

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

@article{84bab62e028b477581c2efb82a69fa84,
title = "Bone mineral density and body composition in lean women with polycystic ovary syndrome",
abstract = "Objective: To examine bone mineral density (BMD) and fat distribution in lean women with polycystic ovary syndrome (PCOS) compared with matched control women. Design: Controlled clinical study. Setting: An academic clinical research center. Patient(s): Twelve non-Hispanic white women with PCOS and a body mass index of <26 and 10 healthy control women matched for age, ethnicity, and weight. Intervention(s): Biometric measures, blood sample collection, and total body/regional bone density and fat analysis were performed. Main Outcome Measure(s): Serum levels of androgens, glucose, and insulin were measured. Bone density and fat distribution were measured by total body dual-energy x-ray absorptiometry. Result(s): Androgen levels were elevated significantly in the lean women with PCOS compared with the controls. There was no statistically significant difference in total body BMD between the two groups. A significant increase in BMD was noted in the left arm, right arm, and left ribs of the lean PCOS group. Evaluation of upper body BMD showed a significant correlation between testosterone levels and BMD. No statistically significant differences were noted in body fat distribution, although the lean PCOS group tended to have lower mean percentages of body fat. Conclusion(s): Lean women with PCOS have regional differences in BMD, with significantly increased BMD in the upper skeleton compared with control women.",
author = "Candace Good and Mark Tulchinsky and David Mauger and Demers, {Laurence M.} and Legro, {Richard S.}",
year = "1999",
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Bone mineral density and body composition in lean women with polycystic ovary syndrome. / Good, Candace; Tulchinsky, Mark; Mauger, David; Demers, Laurence M.; Legro, Richard S.

In: Fertility and sterility, Vol. 72, No. 1, 01.07.1999, p. 21-25.

Research output: Contribution to journalArticle

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