Bone strain and microcracks at stress fracture sites in human metatarsals

S. W. Donahue, N. A. Sharkey, K. A. Modanlou, L. N. Sequeira, R. B. Martin

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Microcracks in bone have been implicated in the development of stress fractures. The goal of this study was to evaluate bone strain and microcracks at locations where stress fractures are common (second metatarsal diaphysis) and rare (fifth metatarsal diaphysis) in an attempt to increase our understanding of the pathogenesis of stress fractures. A dynamic gait simulator was used to simulate normal walking with cadaver feet. The feet were loaded over the entire stance phase of gait and diaphyseal strains were recorded in second and fifth metatarsals. Microcrack density (Cr.Dn) and surface density (Cr.S.Dn) were determined in metatarsal cross sections from the contralateral feet. Bone strain was significantly higher in second metatarsals (-1897 ± 613 microstrain) than in fifth metatarsals (-908 ± 503 microstrain). However, second metatarsal Cr.Dn (0.23 ± 0.15 #/mm2) was not significantly different from fifth metatarsal Cr.Dn (0.35 ± 0.19 #/mm2). There was also no significant difference between Cr.S.Dn in second (17.64 ± 10.99 μm/mm2) and fifth (26.70 ± 15.53 μm/mm2) metatarsals. There were no significant relationships between the microcrack parameters and peak strain in either metatarsal. Cracks that occurred in trabecular struts (92 ± 33 μm) were significantly longer than those found ending at cement lines (71 ± 15 μm) and within osteons (57 ± 16 μm). There were no significant relationships between the microcrack parameters and age in either metatarsal. Peak strain was more than twofold greater in second metatarsals than in fifth metatarsals for simulations of normal walking; however, microcrack parameters were unable to explain the greater incidence of second metatarsal stress fractures. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)827-833
Number of pages7
JournalBone
Volume27
Issue number6
DOIs
StatePublished - Dec 10 2000

Fingerprint

Stress Fractures
Metatarsal Bones
Bone and Bones
Foot
Diaphyses
Gait
Walking
Haversian System
Cadaver

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

Cite this

Donahue, S. W., Sharkey, N. A., Modanlou, K. A., Sequeira, L. N., & Martin, R. B. (2000). Bone strain and microcracks at stress fracture sites in human metatarsals. Bone, 27(6), 827-833. https://doi.org/10.1016/S8756-3282(00)00402-6
Donahue, S. W. ; Sharkey, N. A. ; Modanlou, K. A. ; Sequeira, L. N. ; Martin, R. B. / Bone strain and microcracks at stress fracture sites in human metatarsals. In: Bone. 2000 ; Vol. 27, No. 6. pp. 827-833.
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abstract = "Microcracks in bone have been implicated in the development of stress fractures. The goal of this study was to evaluate bone strain and microcracks at locations where stress fractures are common (second metatarsal diaphysis) and rare (fifth metatarsal diaphysis) in an attempt to increase our understanding of the pathogenesis of stress fractures. A dynamic gait simulator was used to simulate normal walking with cadaver feet. The feet were loaded over the entire stance phase of gait and diaphyseal strains were recorded in second and fifth metatarsals. Microcrack density (Cr.Dn) and surface density (Cr.S.Dn) were determined in metatarsal cross sections from the contralateral feet. Bone strain was significantly higher in second metatarsals (-1897 ± 613 microstrain) than in fifth metatarsals (-908 ± 503 microstrain). However, second metatarsal Cr.Dn (0.23 ± 0.15 #/mm2) was not significantly different from fifth metatarsal Cr.Dn (0.35 ± 0.19 #/mm2). There was also no significant difference between Cr.S.Dn in second (17.64 ± 10.99 μm/mm2) and fifth (26.70 ± 15.53 μm/mm2) metatarsals. There were no significant relationships between the microcrack parameters and peak strain in either metatarsal. Cracks that occurred in trabecular struts (92 ± 33 μm) were significantly longer than those found ending at cement lines (71 ± 15 μm) and within osteons (57 ± 16 μm). There were no significant relationships between the microcrack parameters and age in either metatarsal. Peak strain was more than twofold greater in second metatarsals than in fifth metatarsals for simulations of normal walking; however, microcrack parameters were unable to explain the greater incidence of second metatarsal stress fractures. Copyright (C) 2000 Elsevier Science Inc.",
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Donahue, SW, Sharkey, NA, Modanlou, KA, Sequeira, LN & Martin, RB 2000, 'Bone strain and microcracks at stress fracture sites in human metatarsals', Bone, vol. 27, no. 6, pp. 827-833. https://doi.org/10.1016/S8756-3282(00)00402-6

Bone strain and microcracks at stress fracture sites in human metatarsals. / Donahue, S. W.; Sharkey, N. A.; Modanlou, K. A.; Sequeira, L. N.; Martin, R. B.

In: Bone, Vol. 27, No. 6, 10.12.2000, p. 827-833.

Research output: Contribution to journalArticle

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T1 - Bone strain and microcracks at stress fracture sites in human metatarsals

AU - Donahue, S. W.

AU - Sharkey, N. A.

AU - Modanlou, K. A.

AU - Sequeira, L. N.

AU - Martin, R. B.

PY - 2000/12/10

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N2 - Microcracks in bone have been implicated in the development of stress fractures. The goal of this study was to evaluate bone strain and microcracks at locations where stress fractures are common (second metatarsal diaphysis) and rare (fifth metatarsal diaphysis) in an attempt to increase our understanding of the pathogenesis of stress fractures. A dynamic gait simulator was used to simulate normal walking with cadaver feet. The feet were loaded over the entire stance phase of gait and diaphyseal strains were recorded in second and fifth metatarsals. Microcrack density (Cr.Dn) and surface density (Cr.S.Dn) were determined in metatarsal cross sections from the contralateral feet. Bone strain was significantly higher in second metatarsals (-1897 ± 613 microstrain) than in fifth metatarsals (-908 ± 503 microstrain). However, second metatarsal Cr.Dn (0.23 ± 0.15 #/mm2) was not significantly different from fifth metatarsal Cr.Dn (0.35 ± 0.19 #/mm2). There was also no significant difference between Cr.S.Dn in second (17.64 ± 10.99 μm/mm2) and fifth (26.70 ± 15.53 μm/mm2) metatarsals. There were no significant relationships between the microcrack parameters and peak strain in either metatarsal. Cracks that occurred in trabecular struts (92 ± 33 μm) were significantly longer than those found ending at cement lines (71 ± 15 μm) and within osteons (57 ± 16 μm). There were no significant relationships between the microcrack parameters and age in either metatarsal. Peak strain was more than twofold greater in second metatarsals than in fifth metatarsals for simulations of normal walking; however, microcrack parameters were unable to explain the greater incidence of second metatarsal stress fractures. Copyright (C) 2000 Elsevier Science Inc.

AB - Microcracks in bone have been implicated in the development of stress fractures. The goal of this study was to evaluate bone strain and microcracks at locations where stress fractures are common (second metatarsal diaphysis) and rare (fifth metatarsal diaphysis) in an attempt to increase our understanding of the pathogenesis of stress fractures. A dynamic gait simulator was used to simulate normal walking with cadaver feet. The feet were loaded over the entire stance phase of gait and diaphyseal strains were recorded in second and fifth metatarsals. Microcrack density (Cr.Dn) and surface density (Cr.S.Dn) were determined in metatarsal cross sections from the contralateral feet. Bone strain was significantly higher in second metatarsals (-1897 ± 613 microstrain) than in fifth metatarsals (-908 ± 503 microstrain). However, second metatarsal Cr.Dn (0.23 ± 0.15 #/mm2) was not significantly different from fifth metatarsal Cr.Dn (0.35 ± 0.19 #/mm2). There was also no significant difference between Cr.S.Dn in second (17.64 ± 10.99 μm/mm2) and fifth (26.70 ± 15.53 μm/mm2) metatarsals. There were no significant relationships between the microcrack parameters and peak strain in either metatarsal. Cracks that occurred in trabecular struts (92 ± 33 μm) were significantly longer than those found ending at cement lines (71 ± 15 μm) and within osteons (57 ± 16 μm). There were no significant relationships between the microcrack parameters and age in either metatarsal. Peak strain was more than twofold greater in second metatarsals than in fifth metatarsals for simulations of normal walking; however, microcrack parameters were unable to explain the greater incidence of second metatarsal stress fractures. Copyright (C) 2000 Elsevier Science Inc.

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