Boolean algebraic structures of the genetic code: Possibilities of applications

Ricardo Grau, Maria C. Del Chavez, Robersy Sanchez Rodriguez, Eberto Morgado, Gladys Casas, Isis Bone

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Authors had reported before two dual Boolean algebras to understand the underlying logic of the genetic code structure. In such Boolean structures, deductions have physico-chemical meaning. We summarize here that these algebraic structures can help us to describe the gene evolution process. Particularly in the experimental confrontation, it was found that most of the mutations of several proteins correspond to deductions in these algebras and they have a small Hamming distance related to their respective wild type. Two applications of the corresponding codification system in bioinformatics problems are also shown. The first one is the classification of mutations in a protein. The other one is related with the problem of detecting donors and acceptors in DNA sequences. Besides, pure mathematical models, Statistical techniques (Decision Trees) and Artificial Intelligence techniques (Bayesian Networks) were used in order to show how to accomplish them to solve these knowledge-discovery practical problems.

Original languageEnglish (US)
Title of host publicationKnowledge Discovery and Emergent Complexity in Bioinformatics - First International Workshop, KDECB 2006, Revised Selected Papers
Pages10-21
Number of pages12
Publication statusPublished - Dec 1 2007
Event1st International Workshop on Knowledge Discovery and Emergent Complexity in Bioinformatics, KDECB 2006 - Ghent, Belgium
Duration: May 10 2006May 10 2006

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4366 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other1st International Workshop on Knowledge Discovery and Emergent Complexity in Bioinformatics, KDECB 2006
CountryBelgium
CityGhent
Period5/10/065/10/06

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All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • Computer Science(all)

Cite this

Grau, R., Del Chavez, M. C., Sanchez Rodriguez, R., Morgado, E., Casas, G., & Bone, I. (2007). Boolean algebraic structures of the genetic code: Possibilities of applications. In Knowledge Discovery and Emergent Complexity in Bioinformatics - First International Workshop, KDECB 2006, Revised Selected Papers (pp. 10-21). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4366 LNBI).