20 Citations (Scopus)

Abstract

The role of various immune cells and intra-cellular components involved in immune responses has been elucidated. We describe how this information can be assembled in the form of causal interaction networks and how the dynamics of these networks can be described by qualitative/semi-qualitative modeling methods even in the absence of knowledge about kinetic constants. Recent models analyze signaling induced by the epidermal growth factor, the stimuli leading to pathological conditions, pathogen induced cellular interactions, and the intra-cellular and cellular signaling involved in the regulation of T cell responses. The models make testable predictions regarding yet undetected interactions, process durations and strengths, and novel therapeutic targets, several of which have been experimentally validated.

Original languageEnglish (US)
Pages (from-to)377-381
Number of pages5
JournalCurrent Opinion in Microbiology
Volume13
Issue number3
DOIs
StatePublished - Jun 1 2010

Fingerprint

Epidermal Growth Factor
T-Lymphocytes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{597d8711cab4486caf37b573b529a914,
title = "Boolean models of within-host immune interactions",
abstract = "The role of various immune cells and intra-cellular components involved in immune responses has been elucidated. We describe how this information can be assembled in the form of causal interaction networks and how the dynamics of these networks can be described by qualitative/semi-qualitative modeling methods even in the absence of knowledge about kinetic constants. Recent models analyze signaling induced by the epidermal growth factor, the stimuli leading to pathological conditions, pathogen induced cellular interactions, and the intra-cellular and cellular signaling involved in the regulation of T cell responses. The models make testable predictions regarding yet undetected interactions, process durations and strengths, and novel therapeutic targets, several of which have been experimentally validated.",
author = "Juilee Thakar and Reka Albert",
year = "2010",
month = "6",
day = "1",
doi = "10.1016/j.mib.2010.04.003",
language = "English (US)",
volume = "13",
pages = "377--381",
journal = "Current Opinion in Microbiology",
issn = "1369-5274",
publisher = "Elsevier Limited",
number = "3",

}

Boolean models of within-host immune interactions. / Thakar, Juilee; Albert, Reka.

In: Current Opinion in Microbiology, Vol. 13, No. 3, 01.06.2010, p. 377-381.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Boolean models of within-host immune interactions

AU - Thakar, Juilee

AU - Albert, Reka

PY - 2010/6/1

Y1 - 2010/6/1

N2 - The role of various immune cells and intra-cellular components involved in immune responses has been elucidated. We describe how this information can be assembled in the form of causal interaction networks and how the dynamics of these networks can be described by qualitative/semi-qualitative modeling methods even in the absence of knowledge about kinetic constants. Recent models analyze signaling induced by the epidermal growth factor, the stimuli leading to pathological conditions, pathogen induced cellular interactions, and the intra-cellular and cellular signaling involved in the regulation of T cell responses. The models make testable predictions regarding yet undetected interactions, process durations and strengths, and novel therapeutic targets, several of which have been experimentally validated.

AB - The role of various immune cells and intra-cellular components involved in immune responses has been elucidated. We describe how this information can be assembled in the form of causal interaction networks and how the dynamics of these networks can be described by qualitative/semi-qualitative modeling methods even in the absence of knowledge about kinetic constants. Recent models analyze signaling induced by the epidermal growth factor, the stimuli leading to pathological conditions, pathogen induced cellular interactions, and the intra-cellular and cellular signaling involved in the regulation of T cell responses. The models make testable predictions regarding yet undetected interactions, process durations and strengths, and novel therapeutic targets, several of which have been experimentally validated.

UR - http://www.scopus.com/inward/record.url?scp=77952888422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952888422&partnerID=8YFLogxK

U2 - 10.1016/j.mib.2010.04.003

DO - 10.1016/j.mib.2010.04.003

M3 - Review article

C2 - 20462786

AN - SCOPUS:77952888422

VL - 13

SP - 377

EP - 381

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

SN - 1369-5274

IS - 3

ER -