Boolean models of within-host immune interactions

Juilee Thakar, Reka Albert

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

The role of various immune cells and intra-cellular components involved in immune responses has been elucidated. We describe how this information can be assembled in the form of causal interaction networks and how the dynamics of these networks can be described by qualitative/semi-qualitative modeling methods even in the absence of knowledge about kinetic constants. Recent models analyze signaling induced by the epidermal growth factor, the stimuli leading to pathological conditions, pathogen induced cellular interactions, and the intra-cellular and cellular signaling involved in the regulation of T cell responses. The models make testable predictions regarding yet undetected interactions, process durations and strengths, and novel therapeutic targets, several of which have been experimentally validated.

Original languageEnglish (US)
Pages (from-to)377-381
Number of pages5
JournalCurrent Opinion in Microbiology
Volume13
Issue number3
DOIs
StatePublished - Jun 1 2010

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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