Borderline operability in hepatectomy patients is associated with higher rates of failure to rescue after severe complications

Bradford J. Kim, Ching Wei D. Tzeng, Amanda B. Cooper, Jean Nicolas Vauthey, Thomas A. Aloia

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background/Objective: To understand the influence of age and comorbidities, this study analyzed the incidence and risk factors for post-hepatectomy morbidity/mortality in patients with “borderline” (BL) operability, defined by the preoperative factors: age ≥75 years, dependent function, lung disease, ascites/varices, myocardial infarction, stroke, steroids, weight loss >10%, and/or sepsis. Methods: All elective hepatectomies were identified in the 2005–2013 ACS-NSQIP database. Predictors of 30-day morbidity/mortality in BL patients were analyzed. Results: A 3,574/15,920 (22.4%) patients met BL criteria. Despite non-BL and BL patients undergoing similar magnitude hepatectomies (P > 0.4), BL patients had higher severe complication (SC, 23.3% vs. 15.3%) and mortality rates (3.7% vs. 1.2%, P < 0.001). BL patients with any SC experienced a 14.1% mortality rate (vs. 7.3%, non-BL, P < 0.001). Independent risk factors for SC in BL patients included American Society of Anesthesiologists (ASA) score >3 (odds ratio, OR – 1.29), smoking (OR – 1.41), albumin <3.5 g/dl (OR – 1.36), bilirubin >1 (OR – 2.21), operative time >240 min (OR – 1.58), additional colorectal procedure (OR – 1.78), and concurrent procedure (OR – 1.73, all P < 0.05). Independent predictors of mortality included disseminated cancer (OR – 0.44), albumin <3.5 g/dl (OR – 1.94), thrombocytopenia (OR – 1.95), and extended/right hepatectomy (OR – 2.81, all P < 0.01). Conclusions: Hepatectomy patients meeting BL criteria have an overall post-hepatectomy mortality rate that is triple that of non-BL patients. With less clinical reserve, BL patients who suffer SC are at greater risk of post-hepatectomy death. J. Surg. Oncol. 2017;115:337–343.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalJournal of Surgical Oncology
Volume115
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint

Hepatectomy
Mortality
Albumins
Morbidity
Age Factors
Varicose Veins
Operative Time
Ascites
Thrombocytopenia
Lung Diseases
Comorbidity
Weight Loss
Sepsis
Cohort Studies
Smoking
Stroke
Odds Ratio
Steroids
Myocardial Infarction
Databases

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Kim, Bradford J. ; Tzeng, Ching Wei D. ; Cooper, Amanda B. ; Vauthey, Jean Nicolas ; Aloia, Thomas A. / Borderline operability in hepatectomy patients is associated with higher rates of failure to rescue after severe complications. In: Journal of Surgical Oncology. 2017 ; Vol. 115, No. 3. pp. 337-343.
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title = "Borderline operability in hepatectomy patients is associated with higher rates of failure to rescue after severe complications",
abstract = "Background/Objective: To understand the influence of age and comorbidities, this study analyzed the incidence and risk factors for post-hepatectomy morbidity/mortality in patients with “borderline” (BL) operability, defined by the preoperative factors: age ≥75 years, dependent function, lung disease, ascites/varices, myocardial infarction, stroke, steroids, weight loss >10{\%}, and/or sepsis. Methods: All elective hepatectomies were identified in the 2005–2013 ACS-NSQIP database. Predictors of 30-day morbidity/mortality in BL patients were analyzed. Results: A 3,574/15,920 (22.4{\%}) patients met BL criteria. Despite non-BL and BL patients undergoing similar magnitude hepatectomies (P > 0.4), BL patients had higher severe complication (SC, 23.3{\%} vs. 15.3{\%}) and mortality rates (3.7{\%} vs. 1.2{\%}, P < 0.001). BL patients with any SC experienced a 14.1{\%} mortality rate (vs. 7.3{\%}, non-BL, P < 0.001). Independent risk factors for SC in BL patients included American Society of Anesthesiologists (ASA) score >3 (odds ratio, OR – 1.29), smoking (OR – 1.41), albumin <3.5 g/dl (OR – 1.36), bilirubin >1 (OR – 2.21), operative time >240 min (OR – 1.58), additional colorectal procedure (OR – 1.78), and concurrent procedure (OR – 1.73, all P < 0.05). Independent predictors of mortality included disseminated cancer (OR – 0.44), albumin <3.5 g/dl (OR – 1.94), thrombocytopenia (OR – 1.95), and extended/right hepatectomy (OR – 2.81, all P < 0.01). Conclusions: Hepatectomy patients meeting BL criteria have an overall post-hepatectomy mortality rate that is triple that of non-BL patients. With less clinical reserve, BL patients who suffer SC are at greater risk of post-hepatectomy death. J. Surg. Oncol. 2017;115:337–343.",
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Borderline operability in hepatectomy patients is associated with higher rates of failure to rescue after severe complications. / Kim, Bradford J.; Tzeng, Ching Wei D.; Cooper, Amanda B.; Vauthey, Jean Nicolas; Aloia, Thomas A.

In: Journal of Surgical Oncology, Vol. 115, No. 3, 01.03.2017, p. 337-343.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Borderline operability in hepatectomy patients is associated with higher rates of failure to rescue after severe complications

AU - Kim, Bradford J.

AU - Tzeng, Ching Wei D.

AU - Cooper, Amanda B.

AU - Vauthey, Jean Nicolas

AU - Aloia, Thomas A.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background/Objective: To understand the influence of age and comorbidities, this study analyzed the incidence and risk factors for post-hepatectomy morbidity/mortality in patients with “borderline” (BL) operability, defined by the preoperative factors: age ≥75 years, dependent function, lung disease, ascites/varices, myocardial infarction, stroke, steroids, weight loss >10%, and/or sepsis. Methods: All elective hepatectomies were identified in the 2005–2013 ACS-NSQIP database. Predictors of 30-day morbidity/mortality in BL patients were analyzed. Results: A 3,574/15,920 (22.4%) patients met BL criteria. Despite non-BL and BL patients undergoing similar magnitude hepatectomies (P > 0.4), BL patients had higher severe complication (SC, 23.3% vs. 15.3%) and mortality rates (3.7% vs. 1.2%, P < 0.001). BL patients with any SC experienced a 14.1% mortality rate (vs. 7.3%, non-BL, P < 0.001). Independent risk factors for SC in BL patients included American Society of Anesthesiologists (ASA) score >3 (odds ratio, OR – 1.29), smoking (OR – 1.41), albumin <3.5 g/dl (OR – 1.36), bilirubin >1 (OR – 2.21), operative time >240 min (OR – 1.58), additional colorectal procedure (OR – 1.78), and concurrent procedure (OR – 1.73, all P < 0.05). Independent predictors of mortality included disseminated cancer (OR – 0.44), albumin <3.5 g/dl (OR – 1.94), thrombocytopenia (OR – 1.95), and extended/right hepatectomy (OR – 2.81, all P < 0.01). Conclusions: Hepatectomy patients meeting BL criteria have an overall post-hepatectomy mortality rate that is triple that of non-BL patients. With less clinical reserve, BL patients who suffer SC are at greater risk of post-hepatectomy death. J. Surg. Oncol. 2017;115:337–343.

AB - Background/Objective: To understand the influence of age and comorbidities, this study analyzed the incidence and risk factors for post-hepatectomy morbidity/mortality in patients with “borderline” (BL) operability, defined by the preoperative factors: age ≥75 years, dependent function, lung disease, ascites/varices, myocardial infarction, stroke, steroids, weight loss >10%, and/or sepsis. Methods: All elective hepatectomies were identified in the 2005–2013 ACS-NSQIP database. Predictors of 30-day morbidity/mortality in BL patients were analyzed. Results: A 3,574/15,920 (22.4%) patients met BL criteria. Despite non-BL and BL patients undergoing similar magnitude hepatectomies (P > 0.4), BL patients had higher severe complication (SC, 23.3% vs. 15.3%) and mortality rates (3.7% vs. 1.2%, P < 0.001). BL patients with any SC experienced a 14.1% mortality rate (vs. 7.3%, non-BL, P < 0.001). Independent risk factors for SC in BL patients included American Society of Anesthesiologists (ASA) score >3 (odds ratio, OR – 1.29), smoking (OR – 1.41), albumin <3.5 g/dl (OR – 1.36), bilirubin >1 (OR – 2.21), operative time >240 min (OR – 1.58), additional colorectal procedure (OR – 1.78), and concurrent procedure (OR – 1.73, all P < 0.05). Independent predictors of mortality included disseminated cancer (OR – 0.44), albumin <3.5 g/dl (OR – 1.94), thrombocytopenia (OR – 1.95), and extended/right hepatectomy (OR – 2.81, all P < 0.01). Conclusions: Hepatectomy patients meeting BL criteria have an overall post-hepatectomy mortality rate that is triple that of non-BL patients. With less clinical reserve, BL patients who suffer SC are at greater risk of post-hepatectomy death. J. Surg. Oncol. 2017;115:337–343.

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