Bordetella evolution: Lipid A and Toll-like receptor 4

Iain MacArthur, Paul B. Mann, Eric T. Harvill, Andrew Preston

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalJournal of Endotoxin Research
Volume13
Issue number4
DOIs
StatePublished - Aug 2007

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Molecular Biology
  • Cell Biology
  • Infectious Diseases

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    MacArthur, I., Mann, P. B., Harvill, E. T., & Preston, A. (2007). Bordetella evolution: Lipid A and Toll-like receptor 4. Journal of Endotoxin Research, 13(4), 243-247. https://doi.org/10.1177/0968051907082609