Brain activation patterns associated with working memory in relapsing-remitting MS

Heather A. Wishart, A. J. Saykin, B. C. McDonald, Alexander Mamourian, L. A. Flashman, K. R. Schuschu, K. A. Ryan, C. E. Fadul, L. H. Kasper

Research output: Contribution to journalArticle

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Abstract

Background: Patients with multiple sclerosis (MS) show changes in brain activation patterns during visual and motor tasks that include decreases in the typical local network for a function and increases in other brain regions. Objective: To determine whether brain activation patterns associated with working memory are affected by MS. Methods: Activation of working memory circuitry was examined using an fMRI n-back task in adults with mild relapsing-remitting MS (RRMS; n = 10) and demographically matched healthy controls (n = 10). Results: Group differences in brain activation emerged during both low- and high-demand conditions (p < 0.001). Overall, patients showed less activation than controls in core prefrontal and parietal regions of working memory circuitry, and greater activation in other regions within and beyond typical working memory circuitry, including bilateral medial frontal, cingulate, parietal, bilateral middle temporal, and occipital regions. Conclusions: Relative to controls, patients with mild RRMS showed shifts in brain activation patterns within and beyond typical components of working memory circuitry.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalNeurology
Volume62
Issue number2
DOIs
StatePublished - Jan 27 2004

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Relapsing-Remitting Multiple Sclerosis
Short-Term Memory
Brain
Multiple Sclerosis
Occipital Lobe
Parietal Lobe
Temporal Lobe
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Wishart, H. A., Saykin, A. J., McDonald, B. C., Mamourian, A., Flashman, L. A., Schuschu, K. R., ... Kasper, L. H. (2004). Brain activation patterns associated with working memory in relapsing-remitting MS. Neurology, 62(2), 234-238. https://doi.org/10.1212/01.WNL.0000103238.91536.5F
Wishart, Heather A. ; Saykin, A. J. ; McDonald, B. C. ; Mamourian, Alexander ; Flashman, L. A. ; Schuschu, K. R. ; Ryan, K. A. ; Fadul, C. E. ; Kasper, L. H. / Brain activation patterns associated with working memory in relapsing-remitting MS. In: Neurology. 2004 ; Vol. 62, No. 2. pp. 234-238.
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Wishart, HA, Saykin, AJ, McDonald, BC, Mamourian, A, Flashman, LA, Schuschu, KR, Ryan, KA, Fadul, CE & Kasper, LH 2004, 'Brain activation patterns associated with working memory in relapsing-remitting MS', Neurology, vol. 62, no. 2, pp. 234-238. https://doi.org/10.1212/01.WNL.0000103238.91536.5F

Brain activation patterns associated with working memory in relapsing-remitting MS. / Wishart, Heather A.; Saykin, A. J.; McDonald, B. C.; Mamourian, Alexander; Flashman, L. A.; Schuschu, K. R.; Ryan, K. A.; Fadul, C. E.; Kasper, L. H.

In: Neurology, Vol. 62, No. 2, 27.01.2004, p. 234-238.

Research output: Contribution to journalArticle

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T1 - Brain activation patterns associated with working memory in relapsing-remitting MS

AU - Wishart, Heather A.

AU - Saykin, A. J.

AU - McDonald, B. C.

AU - Mamourian, Alexander

AU - Flashman, L. A.

AU - Schuschu, K. R.

AU - Ryan, K. A.

AU - Fadul, C. E.

AU - Kasper, L. H.

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N2 - Background: Patients with multiple sclerosis (MS) show changes in brain activation patterns during visual and motor tasks that include decreases in the typical local network for a function and increases in other brain regions. Objective: To determine whether brain activation patterns associated with working memory are affected by MS. Methods: Activation of working memory circuitry was examined using an fMRI n-back task in adults with mild relapsing-remitting MS (RRMS; n = 10) and demographically matched healthy controls (n = 10). Results: Group differences in brain activation emerged during both low- and high-demand conditions (p < 0.001). Overall, patients showed less activation than controls in core prefrontal and parietal regions of working memory circuitry, and greater activation in other regions within and beyond typical working memory circuitry, including bilateral medial frontal, cingulate, parietal, bilateral middle temporal, and occipital regions. Conclusions: Relative to controls, patients with mild RRMS showed shifts in brain activation patterns within and beyond typical components of working memory circuitry.

AB - Background: Patients with multiple sclerosis (MS) show changes in brain activation patterns during visual and motor tasks that include decreases in the typical local network for a function and increases in other brain regions. Objective: To determine whether brain activation patterns associated with working memory are affected by MS. Methods: Activation of working memory circuitry was examined using an fMRI n-back task in adults with mild relapsing-remitting MS (RRMS; n = 10) and demographically matched healthy controls (n = 10). Results: Group differences in brain activation emerged during both low- and high-demand conditions (p < 0.001). Overall, patients showed less activation than controls in core prefrontal and parietal regions of working memory circuitry, and greater activation in other regions within and beyond typical working memory circuitry, including bilateral medial frontal, cingulate, parietal, bilateral middle temporal, and occipital regions. Conclusions: Relative to controls, patients with mild RRMS showed shifts in brain activation patterns within and beyond typical components of working memory circuitry.

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