Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks

Nancy Anne Coulter Dennis, Roberto Cabeza, Anna C. Need, Sheena Waters-Metenier, David B. Goldstein, Kevin S. Labar

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophin which has been shown to regulate cell survival and proliferation, as well as synaptic growth and hippocampal long-term potentiation. A naturally occurring single nucleotide polymorphism in the human BDNF gene (val66met) has been associated with altered intercellular trafficking and regulated secretion of BDNF in met compared to val carriers. Additionally, previous studies have found a relationship between the BDNF val66met genotype and functional activity in the hippocampus during episodic and working memory tasks in healthy young adults. Specifically, studies have found that met carriers exhibit both poorer performance and reduced neural activity within the medial temporal lobe (MTL) when performing episodic memory tasks. However, these studies have not been well replicated and have not considered the role of behavioral differences in the interpretation of neural differences. The current study sought to control for cognitive performance in investigating the role of the BDNF val66met genotype on neural activity associated with episodic memory. Across item and relational memory tests, met carriers exhibited increased MTL activation during both encoding and retrieval stages, compared to noncarriers. The results suggest that met carriers are able to recruit MTL activity to support successful memory processes, and reductions in cognitive performance observed in prior studies are not a ubiquitous effect associated with variants of the BDNF val66met genotype.

Original languageEnglish (US)
Pages (from-to)980-989
Number of pages10
JournalHippocampus
Volume21
Issue number9
DOIs
StatePublished - Sep 1 2011

Fingerprint

Brain-Derived Neurotrophic Factor
Episodic Memory
Temporal Lobe
Genotype
Long-Term Potentiation
Nerve Growth Factors
Short-Term Memory
Single Nucleotide Polymorphism
Young Adult
Hippocampus
Cell Survival
Cell Proliferation
Growth
Genes

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience

Cite this

Dennis, Nancy Anne Coulter ; Cabeza, Roberto ; Need, Anna C. ; Waters-Metenier, Sheena ; Goldstein, David B. ; Labar, Kevin S. / Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks. In: Hippocampus. 2011 ; Vol. 21, No. 9. pp. 980-989.
@article{48a265ff86e84673a3ff5a886086b796,
title = "Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks",
abstract = "Brain-derived neurotrophic factor (BDNF) is a neurotrophin which has been shown to regulate cell survival and proliferation, as well as synaptic growth and hippocampal long-term potentiation. A naturally occurring single nucleotide polymorphism in the human BDNF gene (val66met) has been associated with altered intercellular trafficking and regulated secretion of BDNF in met compared to val carriers. Additionally, previous studies have found a relationship between the BDNF val66met genotype and functional activity in the hippocampus during episodic and working memory tasks in healthy young adults. Specifically, studies have found that met carriers exhibit both poorer performance and reduced neural activity within the medial temporal lobe (MTL) when performing episodic memory tasks. However, these studies have not been well replicated and have not considered the role of behavioral differences in the interpretation of neural differences. The current study sought to control for cognitive performance in investigating the role of the BDNF val66met genotype on neural activity associated with episodic memory. Across item and relational memory tests, met carriers exhibited increased MTL activation during both encoding and retrieval stages, compared to noncarriers. The results suggest that met carriers are able to recruit MTL activity to support successful memory processes, and reductions in cognitive performance observed in prior studies are not a ubiquitous effect associated with variants of the BDNF val66met genotype.",
author = "Dennis, {Nancy Anne Coulter} and Roberto Cabeza and Need, {Anna C.} and Sheena Waters-Metenier and Goldstein, {David B.} and Labar, {Kevin S.}",
year = "2011",
month = "9",
day = "1",
doi = "10.1002/hipo.20809",
language = "English (US)",
volume = "21",
pages = "980--989",
journal = "Hippocampus",
issn = "1050-9631",
publisher = "Wiley-Liss Inc.",
number = "9",

}

Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks. / Dennis, Nancy Anne Coulter; Cabeza, Roberto; Need, Anna C.; Waters-Metenier, Sheena; Goldstein, David B.; Labar, Kevin S.

In: Hippocampus, Vol. 21, No. 9, 01.09.2011, p. 980-989.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks

AU - Dennis, Nancy Anne Coulter

AU - Cabeza, Roberto

AU - Need, Anna C.

AU - Waters-Metenier, Sheena

AU - Goldstein, David B.

AU - Labar, Kevin S.

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Brain-derived neurotrophic factor (BDNF) is a neurotrophin which has been shown to regulate cell survival and proliferation, as well as synaptic growth and hippocampal long-term potentiation. A naturally occurring single nucleotide polymorphism in the human BDNF gene (val66met) has been associated with altered intercellular trafficking and regulated secretion of BDNF in met compared to val carriers. Additionally, previous studies have found a relationship between the BDNF val66met genotype and functional activity in the hippocampus during episodic and working memory tasks in healthy young adults. Specifically, studies have found that met carriers exhibit both poorer performance and reduced neural activity within the medial temporal lobe (MTL) when performing episodic memory tasks. However, these studies have not been well replicated and have not considered the role of behavioral differences in the interpretation of neural differences. The current study sought to control for cognitive performance in investigating the role of the BDNF val66met genotype on neural activity associated with episodic memory. Across item and relational memory tests, met carriers exhibited increased MTL activation during both encoding and retrieval stages, compared to noncarriers. The results suggest that met carriers are able to recruit MTL activity to support successful memory processes, and reductions in cognitive performance observed in prior studies are not a ubiquitous effect associated with variants of the BDNF val66met genotype.

AB - Brain-derived neurotrophic factor (BDNF) is a neurotrophin which has been shown to regulate cell survival and proliferation, as well as synaptic growth and hippocampal long-term potentiation. A naturally occurring single nucleotide polymorphism in the human BDNF gene (val66met) has been associated with altered intercellular trafficking and regulated secretion of BDNF in met compared to val carriers. Additionally, previous studies have found a relationship between the BDNF val66met genotype and functional activity in the hippocampus during episodic and working memory tasks in healthy young adults. Specifically, studies have found that met carriers exhibit both poorer performance and reduced neural activity within the medial temporal lobe (MTL) when performing episodic memory tasks. However, these studies have not been well replicated and have not considered the role of behavioral differences in the interpretation of neural differences. The current study sought to control for cognitive performance in investigating the role of the BDNF val66met genotype on neural activity associated with episodic memory. Across item and relational memory tests, met carriers exhibited increased MTL activation during both encoding and retrieval stages, compared to noncarriers. The results suggest that met carriers are able to recruit MTL activity to support successful memory processes, and reductions in cognitive performance observed in prior studies are not a ubiquitous effect associated with variants of the BDNF val66met genotype.

UR - http://www.scopus.com/inward/record.url?scp=80051928161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051928161&partnerID=8YFLogxK

U2 - 10.1002/hipo.20809

DO - 10.1002/hipo.20809

M3 - Article

C2 - 20865733

AN - SCOPUS:80051928161

VL - 21

SP - 980

EP - 989

JO - Hippocampus

JF - Hippocampus

SN - 1050-9631

IS - 9

ER -