Brain localization of cholinergic influence on male sex behavior in rats: Antagonists

E. M. Hull, E. A. Pehek, D. Bitran, Gregory Holmes, R. K. Warner, L. C. Band, T. Bazzett, L. G. Clemens

Research output: Contribution to journalArticle

Abstract

The muscarinic receptor antagonist scopolamine was microinjected into either the preoptic area or the lateral ventricle, preceding sexual behavior tests. In Experiment 1 unilateral ventricular injections of scopolamine delayed the initiation of copulation, while unilateral preoptic injections had no effect. In Experiment 2 bilateral injections into the preoptic area produced dose-related decreases in the percentages of animals intromitting and ejaculating. In Experiment 3 scopolamine, injected alone into the preoptic area, again decreased the percentages of animals mounting, intromitting, and ejaculating. The muscarinic agonist oxotremorine, injected alone into the preoptic area, decreased ejaculatory threshold (i.e., decreased the number of intromissions preceding ejaculation) as previously reported. Concurrent oxotremorine and scopolamine injections into the preoptic area were not different from vehicle; thus, scopolamine blocked oxotremorine's effect. These data suggest that some cholinergic activation of the preoptic area is critical for normal copulation, since bilateral blockade of muscarinic receptors there dramatically decreased the number of animals copulating. However, increased cholinergic activity there only reduced ejaculation threshold.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalPharmacology Biochemistry and Behavior
Volume31
Issue number1
StatePublished - Dec 1 1988

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Preoptic Area
Scopolamine Hydrobromide
Sexual Behavior
Cholinergic Agents
Rats
Brain
Oxotremorine
Animals
Copulation
Muscarinic Receptors
Ejaculation
Injections
Muscarinic Agonists
Experiments
Muscarinic Antagonists
Mountings
Lateral Ventricles
Chemical activation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Hull, E. M., Pehek, E. A., Bitran, D., Holmes, G., Warner, R. K., Band, L. C., ... Clemens, L. G. (1988). Brain localization of cholinergic influence on male sex behavior in rats: Antagonists. Pharmacology Biochemistry and Behavior, 31(1), 175-178.
Hull, E. M. ; Pehek, E. A. ; Bitran, D. ; Holmes, Gregory ; Warner, R. K. ; Band, L. C. ; Bazzett, T. ; Clemens, L. G. / Brain localization of cholinergic influence on male sex behavior in rats : Antagonists. In: Pharmacology Biochemistry and Behavior. 1988 ; Vol. 31, No. 1. pp. 175-178.
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Hull, EM, Pehek, EA, Bitran, D, Holmes, G, Warner, RK, Band, LC, Bazzett, T & Clemens, LG 1988, 'Brain localization of cholinergic influence on male sex behavior in rats: Antagonists', Pharmacology Biochemistry and Behavior, vol. 31, no. 1, pp. 175-178.

Brain localization of cholinergic influence on male sex behavior in rats : Antagonists. / Hull, E. M.; Pehek, E. A.; Bitran, D.; Holmes, Gregory; Warner, R. K.; Band, L. C.; Bazzett, T.; Clemens, L. G.

In: Pharmacology Biochemistry and Behavior, Vol. 31, No. 1, 01.12.1988, p. 175-178.

Research output: Contribution to journalArticle

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