Brain localization of cholinergic influence on male sex behavior in rats: Agonists

Elaine M. Hull, Daniel Bitran, Elizabeth A. Pehek, Gregory Holmes, Robert K. Warner, Linda C. Band, Lynwood G. Clemens

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Cholinergic agonists were microinjected into either the lateral ventricle or the preoptic area of sexually experienced male rats. In Experiment 1 carbachol, injected into the lateral ventricles, delayed the initiation of sexual behavior. When injected into the preoptic area, carbachol again delayed the onset of copulation, but these delays were shorter than after ventricular injections. In addition, preoptic injections reduced the number of intromissions preceding ejaculation. In Experiment 2 ventricular injections of the muscarinic agonist oxotremorine again delayed initiation of sexual behavior and also slowed its rate. However, oxotremorine injections into the preoptic area, through cannulae angled to miss all ventricles, only decreased the number of intromissions preceding ejaculation. These data suggest that cholinergic synapses in proximity to the ventricles may decrease sexual arousal, while cholinergic mechanisms in or near the preoptic area may reduce ejaculatory threshold.

Original languageEnglish (US)
Pages (from-to)169-174
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume31
Issue number1
DOIs
StatePublished - Jan 1 1988

Fingerprint

Oxotremorine
Preoptic Area
Carbachol
Sexual Behavior
Cholinergic Agents
Rats
Brain
Cholinergic Agonists
Muscarinic Agonists
Ejaculation
Injections
Lateral Ventricles
Experiments
Copulation
Arousal
Synapses

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Hull, Elaine M. ; Bitran, Daniel ; Pehek, Elizabeth A. ; Holmes, Gregory ; Warner, Robert K. ; Band, Linda C. ; Clemens, Lynwood G. / Brain localization of cholinergic influence on male sex behavior in rats : Agonists. In: Pharmacology, Biochemistry and Behavior. 1988 ; Vol. 31, No. 1. pp. 169-174.
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Brain localization of cholinergic influence on male sex behavior in rats : Agonists. / Hull, Elaine M.; Bitran, Daniel; Pehek, Elizabeth A.; Holmes, Gregory; Warner, Robert K.; Band, Linda C.; Clemens, Lynwood G.

In: Pharmacology, Biochemistry and Behavior, Vol. 31, No. 1, 01.01.1988, p. 169-174.

Research output: Contribution to journalArticle

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