Brain-on-a-chip: Design and modeling

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Abstract

The aim of this paper is to lay the foundations of the basic science that will guide the design and making of an implantable neuro-glial-vascular unit optimized to perform certain fundamental processes that could facilitate monitoring and supporting the proper functionality of the brain. Such an engineered unit is called brain-on-a-chip. We first provide a possible structure of a brain-on-a-chip and then focus on the mathematical modeling of the coupled mechano-electrochemistry of a neuron and its membrane. We propose a constrained Lagrangian formulation that links the Hodgkin-Huxley model of the electronic membrane and the motion and diffusion processes of a triphasic porous medium that fills the inside of the neuron. The three phases of the triphasic medium are: solid, fluid and ionic. Lastly, a simplified Lagrangian formulation more suitable for practical applications is given whose corresponding Euler-Lagrange equations are obtained from the non-conservative form of Hamilton’s principle.

Original languageEnglish (US)
Pages (from-to)147-162
Number of pages16
JournalDynamics of Continuous, Discrete and Impulsive Systems Series B: Applications and Algorithms
Volume25
Issue number3-4
StatePublished - Jan 1 2018

All Science Journal Classification (ASJC) codes

  • Discrete Mathematics and Combinatorics
  • Applied Mathematics

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