Brain spectrin (240/235) and brain spectrin (240/235E): Two distinct spectrin subtypes with different locations within mammalian neural cells

B. M. Riederer, I. S. Zagon, S. R. Goodman

Research output: Contribution to journalArticlepeer-review

175 Scopus citations

Abstract

Adult mouse brain contains at least two distinct spectrin subtypes, both consisting of 240-kD and 235-kD subunits. Brain spectrin(240/235) is found in neuronal axons, but not dendrites, when immunohistochemistry is performed with antibody raised against brain spectrin isolated from enriched synaptic/axonal membranes. A second spectrin subtype, brain spectrin(240/235E), is exclusively recognized by red blood cell spectrin antibody. Brain spectrin (240/235E) is confined to neuronal cell bodies and dendrites, and some glial cells, but is not present in axons or presynaptic terminals.

Original languageEnglish (US)
Pages (from-to)2088-2097
Number of pages10
JournalJournal of Cell Biology
Volume102
Issue number6
DOIs
StatePublished - 1986

All Science Journal Classification (ASJC) codes

  • Cell Biology

Fingerprint Dive into the research topics of 'Brain spectrin (240/235) and brain spectrin (240/235E): Two distinct spectrin subtypes with different locations within mammalian neural cells'. Together they form a unique fingerprint.

Cite this