Abstract

Oxidative stress/damage resulting from exposure to cigarette smoke plays a critical role in the development of tobacco-caused diseases. Carbonyls and free radicals are two major classes of oxidants in tobacco smoke. There is little information on the combined delivery of these oxidants across different cigarette brands; thus, we set out to measure and compare their levels in mainstream smoke from popular US cigarettes. Mainstream smoke from 28 different cigarette brands produced by smoking (FTC protocol) was analyzed for five important, abundant carbonyls, and levels were compared to previously determined free radical for the same brands. Overall, there were large variations (3- to 6-fold) in carbonyl levels across brands with total carbonyl levels ranging from 275 to 804 μg/cigarette, which persisted even after adjusting for ventilation. Individual carbonyl levels were highly correlated with each other (r2: 0.40–0.95, P < 0.003) except for formaldehyde. Both gas-phase (r2: 0.37, P = 0.006) and particulate-phase (r2: 0.27, P = 0.005) free radicals were correlated to total carbonyl content; however, this correlation disappeared after adjusting for ventilation. These data show that overall oxidant production varies widely by cigarette brand and the resulting difference in oxidant burden could potentially lead to differences in disease risk.

Original languageEnglish (US)
Pages (from-to)147-154
Number of pages8
JournalFood and Chemical Toxicology
Volume106
DOIs
StatePublished - Aug 1 2017

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cigarettes
smoke
Oxidants
oxidants
Smoke
Tobacco Products
Free Radicals
Tobacco
Ventilation
tobacco
Oxidative stress
formaldehyde
Formaldehyde
particulates
Oxidative Stress
oxidative stress
Gases
Smoking
gases

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

Cite this

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title = "Brand variation in oxidant production in mainstream cigarette smoke: Carbonyls and free radicals",
abstract = "Oxidative stress/damage resulting from exposure to cigarette smoke plays a critical role in the development of tobacco-caused diseases. Carbonyls and free radicals are two major classes of oxidants in tobacco smoke. There is little information on the combined delivery of these oxidants across different cigarette brands; thus, we set out to measure and compare their levels in mainstream smoke from popular US cigarettes. Mainstream smoke from 28 different cigarette brands produced by smoking (FTC protocol) was analyzed for five important, abundant carbonyls, and levels were compared to previously determined free radical for the same brands. Overall, there were large variations (3- to 6-fold) in carbonyl levels across brands with total carbonyl levels ranging from 275 to 804 μg/cigarette, which persisted even after adjusting for ventilation. Individual carbonyl levels were highly correlated with each other (r2: 0.40–0.95, P < 0.003) except for formaldehyde. Both gas-phase (r2: 0.37, P = 0.006) and particulate-phase (r2: 0.27, P = 0.005) free radicals were correlated to total carbonyl content; however, this correlation disappeared after adjusting for ventilation. These data show that overall oxidant production varies widely by cigarette brand and the resulting difference in oxidant burden could potentially lead to differences in disease risk.",
author = "Reilly, {Samantha M.} and Reema Goel and Neil Trushin and Ryan Elias and Jonathan Foulds and Joshua Muscat and Liao, {Jiangang (Jason)} and John Richie",
year = "2017",
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language = "English (US)",
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T2 - Carbonyls and free radicals

AU - Reilly, Samantha M.

AU - Goel, Reema

AU - Trushin, Neil

AU - Elias, Ryan

AU - Foulds, Jonathan

AU - Muscat, Joshua

AU - Liao, Jiangang (Jason)

AU - Richie, John

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