Brefeldin A inhibits protein synthesis through the phosphorylation of the α-subunit of eukaryotic initiation factor-2

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Abstract

Brefeldin A is a fungal metabolite which disrupts protein traffic through the Golgi apparatus and thereby inhibits protein secretion. Recently, it has been shown that Brefeldin A also causes a marked decrease in the rate of protein synthesis in cells in culture [1992, FEBS Lett. 314, 371-374]. We show here that treatment of rat GH3 pituitary cells with Brefeldin A leads to an inhibition of protein synthesis at the level of peptide-chain initiation through a mechanism involving the phosphorylation of the α-subunit of eukaryotic initiation factor-2 (eIF-2α).

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalFEBS Letters
Volume350
Issue number1
DOIs
StatePublished - Aug 15 1994

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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