Bridging scales in the evolution of infectious disease life histories: Application

Nicole Mideo, William A. Nelson, Sarah E. Reece, Andrew Stuart Bell, Andrew Fraser Read, Troy Day

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Within- and between-host disease processes occur on the same timescales, therefore changes in the within-host dynamics of parasites, resources, and immunity can interact with changes in the epidemiological dynamics to affect evolutionary outcomes. Consequently, studies of the evolution of disease life histories, that is, infection-age-specific patterns of transmission and virulence, have been constrained by the need for a mechanistic understanding of within-host disease dynamics. In a companion paper (Day et al. 2011), we develop a novel approach that quantifies the relevant within-host aspects of disease through genetic covariance functions. Here, we demonstrate how to apply this theory to data. Using two previously published datasets from rodent malaria infections, we show how to translate experimental measures into disease life-history traits, and how to quantify the covariance in these traits. Our results show how patterns of covariance can interact with epidemiological dynamics to affect evolutionary predictions for disease life history. We also find that the selective constraints on disease life-history evolution can vary qualitatively, and that "simple" virulence-transmission trade-offs that are often the subject of experimental investigation can be obscured by trade-offs within one trait alone. Finally, we highlight the type and quality of data required for future applications.

Original languageEnglish (US)
Pages (from-to)3298-3310
Number of pages13
JournalEvolution
Volume65
Issue number11
DOIs
StatePublished - Nov 1 2011

Fingerprint

infectious disease
infectious diseases
Communicable Diseases
life history
virulence
genetic covariance
Virulence
infection
malaria
Inborn Genetic Diseases
rodents
immunity
Infection
parasites
Malaria
prediction
life history trait
Immunity
Rodentia
Parasites

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Agricultural and Biological Sciences(all)

Cite this

Mideo, Nicole ; Nelson, William A. ; Reece, Sarah E. ; Bell, Andrew Stuart ; Read, Andrew Fraser ; Day, Troy. / Bridging scales in the evolution of infectious disease life histories : Application. In: Evolution. 2011 ; Vol. 65, No. 11. pp. 3298-3310.
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Bridging scales in the evolution of infectious disease life histories : Application. / Mideo, Nicole; Nelson, William A.; Reece, Sarah E.; Bell, Andrew Stuart; Read, Andrew Fraser; Day, Troy.

In: Evolution, Vol. 65, No. 11, 01.11.2011, p. 3298-3310.

Research output: Contribution to journalArticle

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