@article{dce4317436af49659982e5fa9f075e84,
title = "Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in drosophila",
abstract = "To advance our understanding of adaptation to temporally varying selection pressures, we identified signatures of seasonal adaptation occurring in parallel among Drosophila melanogaster populations. Specifically, we estimated allele frequencies genome-wide from flies sampled early and late in the growing season from 20 widely dispersed populations. We identified parallel seasonal allele frequency shifts across North America and Europe, demonstrating that seasonal adaptation is a general phenomenon of temperate fly populations. Seasonally fluctuating polymorphisms are enriched in large chromosomal inversions and we find a broad concordance between seasonal and spatial allele frequency change. The direction of allele frequency change at seasonally variable polymorphisms can be predicted by weather conditions in the weeks prior to sampling, linking the environment and the genomic response to selection. Our results suggest that fluctuating selection is an important evolutionary force affecting patterns of genetic variation in Drosophila.",
author = "Machado, {Heather E.} and Bergland, {Alan O.} and Ryan Taylor and Susanne Tilk and Emily Behrman and Kelly Dyer and Fabian, {Daniel K.} and Thomas Flatt and Josefa Gonz{\'a}lez and Karasov, {Talia L.} and Bernard Kim and Iryna Kozeretska and Lazzaro, {Brian P.} and Merritt, {Thomas J.S.} and Pool, {John E.} and Katherine O{\textquoteright}brien and Subhash Rajpurohit and Roy, {Paula R.} and Schaeffer, {Stephen W.} and Svitlana Serga and Paul Schmidt and Petrov, {Dmitri A.}",
note = "Funding Information: We thank the National Evolutionary Synthesis Center (NESCent) for sponsoring the 2012 Catalysis meeting that initiated the Drosophila Real Time Evolution Consortium. The meeting was attended by Alan Bergland, Alisa Sedghifar, Brian Helmuth, Brian Lazzarro, Chau-Ti Ting, David Kidd, Dmitri Petrov, Fabian Staubach, Hannah Burrack, Jim Fry, John Lessard, John Coulbourne, John Pool, Josefa Gonzalez, Julien Ayroles, Kelly Dyer, Kim Hughes, Maaria Kankare, Nadia Singh, Paul Schmidt, Regan Early, Stephen Porder, Subhash Rajpurohit, Sui Fai Lee, and Thomas Flatt, and we kindly thank all participants for their participation. We also thank Jamie Blundell and all members of the Schmidt and Petrov labs who provided exceptionally valuable feedback. This work was funded by the NIH grants R01GM100366 to PS and DAP, R35GM118165 to DAP, R01GM100366 and R01GM137430 to PS, F32GM097837 and R35GM119686 to AOB, European Commission grant H2020-ERC-2014-CoG-647900 to JG, a NSERC Discovery Grant RGPIN-2018-05551 and Canada Research Chair 950-230113 to TJSM. Publisher Copyright: {\textcopyright} 2021, eLife Sciences Publications Ltd. All rights reserved.",
year = "2021",
month = jun,
doi = "10.7554/eLife.67577",
language = "English (US)",
volume = "10",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
}