Bronchial vascular contribution to lung lymph flow

Elizabeth M. Wagner, Sandralee Blosser, Wayne Mitzner

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The lymphatic vessels of the lung provide an important route for clearance of interstitial edema fluid filtered from pulmonary blood vessels. However, the importance of lung lymphatics for the removal of airway liquid filtered from the systemic circulation of the lung has not been demonstrated. We studied the contribution of the bronchial vasculature to lung lymph flow in anesthetized, ventilated sheep (n = 35). With the bronchial artery cannulated and perfused (control flow = 0.6 ml · min-1 · kg-1), lymph flow from the efferent duct of the caudal mediastinal lymph node was measured 1) during increased bronchial vascular perfusion (300% of control flow); 2) with a hydrated interstitium induced by a 1-h period of left atrial hypertension and subsequent recovery, both with and without bronchial perfusion; and 3) during infusion (directly into the bronchial artery) of bradykinin, an inflammatory mediator known to cause changes in bronchial vascular permeability. Increased bronchial perfusion for 90 min resulted in an average 35% increase in lung lymph flow. During left atrial hypertension, the increase in lung lymph flow was significantly greater with bronchial perfusion (339% increase over baseline) than without bronchial perfusion (138% increase). Furthermore, recovery after left atrial hypertension was more complete after 90 min without bronchial perfusion (91%) than with bronchial perfusion (63%). Infusion of bradykinin into the bronchial artery resulted in a prompt and prolonged 107% increase in lung lymph flow. This was not seen if the same dose was infused into the pulmonary artery. Thus bronchial vascular transudate contributes significantly to lymph flow from the efferent duct of the caudal mediastinal lymph node. These results demonstrate that lymph vessels clear excess fluid from the airway wall and should be considered when evaluating the effect of vascular leak in airway obstruction.

Original languageEnglish (US)
Pages (from-to)2190-2195
Number of pages6
JournalJournal of Applied Physiology
Volume85
Issue number6
DOIs
StatePublished - Jan 1 1998

Fingerprint

Lymph
Blood Vessels
Perfusion
Lung
Bronchial Arteries
Bradykinin
Hypertension
Lymph Nodes
Lymphatic Vessels
Extracellular Fluid
Capillary Permeability
Exudates and Transudates
Airway Obstruction
Pulmonary Artery
Edema
Sheep

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Wagner, Elizabeth M. ; Blosser, Sandralee ; Mitzner, Wayne. / Bronchial vascular contribution to lung lymph flow. In: Journal of Applied Physiology. 1998 ; Vol. 85, No. 6. pp. 2190-2195.
@article{0348fd4d35e84cd6a042651b892419cf,
title = "Bronchial vascular contribution to lung lymph flow",
abstract = "The lymphatic vessels of the lung provide an important route for clearance of interstitial edema fluid filtered from pulmonary blood vessels. However, the importance of lung lymphatics for the removal of airway liquid filtered from the systemic circulation of the lung has not been demonstrated. We studied the contribution of the bronchial vasculature to lung lymph flow in anesthetized, ventilated sheep (n = 35). With the bronchial artery cannulated and perfused (control flow = 0.6 ml · min-1 · kg-1), lymph flow from the efferent duct of the caudal mediastinal lymph node was measured 1) during increased bronchial vascular perfusion (300{\%} of control flow); 2) with a hydrated interstitium induced by a 1-h period of left atrial hypertension and subsequent recovery, both with and without bronchial perfusion; and 3) during infusion (directly into the bronchial artery) of bradykinin, an inflammatory mediator known to cause changes in bronchial vascular permeability. Increased bronchial perfusion for 90 min resulted in an average 35{\%} increase in lung lymph flow. During left atrial hypertension, the increase in lung lymph flow was significantly greater with bronchial perfusion (339{\%} increase over baseline) than without bronchial perfusion (138{\%} increase). Furthermore, recovery after left atrial hypertension was more complete after 90 min without bronchial perfusion (91{\%}) than with bronchial perfusion (63{\%}). Infusion of bradykinin into the bronchial artery resulted in a prompt and prolonged 107{\%} increase in lung lymph flow. This was not seen if the same dose was infused into the pulmonary artery. Thus bronchial vascular transudate contributes significantly to lymph flow from the efferent duct of the caudal mediastinal lymph node. These results demonstrate that lymph vessels clear excess fluid from the airway wall and should be considered when evaluating the effect of vascular leak in airway obstruction.",
author = "Wagner, {Elizabeth M.} and Sandralee Blosser and Wayne Mitzner",
year = "1998",
month = "1",
day = "1",
doi = "10.1152/jappl.1998.85.6.2190",
language = "English (US)",
volume = "85",
pages = "2190--2195",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "6",

}

Bronchial vascular contribution to lung lymph flow. / Wagner, Elizabeth M.; Blosser, Sandralee; Mitzner, Wayne.

In: Journal of Applied Physiology, Vol. 85, No. 6, 01.01.1998, p. 2190-2195.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bronchial vascular contribution to lung lymph flow

AU - Wagner, Elizabeth M.

AU - Blosser, Sandralee

AU - Mitzner, Wayne

PY - 1998/1/1

Y1 - 1998/1/1

N2 - The lymphatic vessels of the lung provide an important route for clearance of interstitial edema fluid filtered from pulmonary blood vessels. However, the importance of lung lymphatics for the removal of airway liquid filtered from the systemic circulation of the lung has not been demonstrated. We studied the contribution of the bronchial vasculature to lung lymph flow in anesthetized, ventilated sheep (n = 35). With the bronchial artery cannulated and perfused (control flow = 0.6 ml · min-1 · kg-1), lymph flow from the efferent duct of the caudal mediastinal lymph node was measured 1) during increased bronchial vascular perfusion (300% of control flow); 2) with a hydrated interstitium induced by a 1-h period of left atrial hypertension and subsequent recovery, both with and without bronchial perfusion; and 3) during infusion (directly into the bronchial artery) of bradykinin, an inflammatory mediator known to cause changes in bronchial vascular permeability. Increased bronchial perfusion for 90 min resulted in an average 35% increase in lung lymph flow. During left atrial hypertension, the increase in lung lymph flow was significantly greater with bronchial perfusion (339% increase over baseline) than without bronchial perfusion (138% increase). Furthermore, recovery after left atrial hypertension was more complete after 90 min without bronchial perfusion (91%) than with bronchial perfusion (63%). Infusion of bradykinin into the bronchial artery resulted in a prompt and prolonged 107% increase in lung lymph flow. This was not seen if the same dose was infused into the pulmonary artery. Thus bronchial vascular transudate contributes significantly to lymph flow from the efferent duct of the caudal mediastinal lymph node. These results demonstrate that lymph vessels clear excess fluid from the airway wall and should be considered when evaluating the effect of vascular leak in airway obstruction.

AB - The lymphatic vessels of the lung provide an important route for clearance of interstitial edema fluid filtered from pulmonary blood vessels. However, the importance of lung lymphatics for the removal of airway liquid filtered from the systemic circulation of the lung has not been demonstrated. We studied the contribution of the bronchial vasculature to lung lymph flow in anesthetized, ventilated sheep (n = 35). With the bronchial artery cannulated and perfused (control flow = 0.6 ml · min-1 · kg-1), lymph flow from the efferent duct of the caudal mediastinal lymph node was measured 1) during increased bronchial vascular perfusion (300% of control flow); 2) with a hydrated interstitium induced by a 1-h period of left atrial hypertension and subsequent recovery, both with and without bronchial perfusion; and 3) during infusion (directly into the bronchial artery) of bradykinin, an inflammatory mediator known to cause changes in bronchial vascular permeability. Increased bronchial perfusion for 90 min resulted in an average 35% increase in lung lymph flow. During left atrial hypertension, the increase in lung lymph flow was significantly greater with bronchial perfusion (339% increase over baseline) than without bronchial perfusion (138% increase). Furthermore, recovery after left atrial hypertension was more complete after 90 min without bronchial perfusion (91%) than with bronchial perfusion (63%). Infusion of bradykinin into the bronchial artery resulted in a prompt and prolonged 107% increase in lung lymph flow. This was not seen if the same dose was infused into the pulmonary artery. Thus bronchial vascular transudate contributes significantly to lymph flow from the efferent duct of the caudal mediastinal lymph node. These results demonstrate that lymph vessels clear excess fluid from the airway wall and should be considered when evaluating the effect of vascular leak in airway obstruction.

UR - http://www.scopus.com/inward/record.url?scp=0031766782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031766782&partnerID=8YFLogxK

U2 - 10.1152/jappl.1998.85.6.2190

DO - 10.1152/jappl.1998.85.6.2190

M3 - Article

VL - 85

SP - 2190

EP - 2195

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 6

ER -