Bronchoalveolar lavage cells and proteins in patients with the acquired immunodeficiency syndrome. An immunologic analysis.

K. R. Young, J. A. Rankin, G. P. Naegel, E. S. Paul, Herbert Reynolds

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Several components of cellular and humoral immunity were examined in bronchoalveolar lavage fluid and blood of 15 patients with the acquired immunodeficiency syndrome, and the results were compared to data from 25 healthy controls (including 5 asymptomatic homosexual men). Compared with that of controls, bronchoalveolar lavage fluid from patients tended to have more lymphocytes and significantly more neutrophils; a lower OKT4/OKT8 ratio, due to an increase in total OKT8 cells; and normal total OKT4 cell counts, despite a significant decrease in numbers of OKT4 cells in peripheral blood. Patients also had significantly more IgG-releasing cells and higher IgG levels than controls in lavage fluid. These data show that, in the lung lining fluid of patients with the acquired immunodeficiency syndrome, significant alterations in cellular and humoral immunity exist that differ in several important respects from immunity in controls and from corresponding changes in patients' peripheral blood.

Original languageEnglish (US)
Pages (from-to)522-533
Number of pages12
JournalAnnals of internal medicine
Volume103
Issue number4
StatePublished - Oct 1 1985

Fingerprint

Bronchoalveolar Lavage
Acquired Immunodeficiency Syndrome
Bronchoalveolar Lavage Fluid
Humoral Immunity
Proteins
Cellular Immunity
Cell Count
Immunoglobulin G
Therapeutic Irrigation
Immunity
Neutrophils
Lymphocytes
Lung

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Young, K. R., Rankin, J. A., Naegel, G. P., Paul, E. S., & Reynolds, H. (1985). Bronchoalveolar lavage cells and proteins in patients with the acquired immunodeficiency syndrome. An immunologic analysis. Annals of internal medicine, 103(4), 522-533.
Young, K. R. ; Rankin, J. A. ; Naegel, G. P. ; Paul, E. S. ; Reynolds, Herbert. / Bronchoalveolar lavage cells and proteins in patients with the acquired immunodeficiency syndrome. An immunologic analysis. In: Annals of internal medicine. 1985 ; Vol. 103, No. 4. pp. 522-533.
@article{9b9e7174a0594a1598ed7be73eb6c8af,
title = "Bronchoalveolar lavage cells and proteins in patients with the acquired immunodeficiency syndrome. An immunologic analysis.",
abstract = "Several components of cellular and humoral immunity were examined in bronchoalveolar lavage fluid and blood of 15 patients with the acquired immunodeficiency syndrome, and the results were compared to data from 25 healthy controls (including 5 asymptomatic homosexual men). Compared with that of controls, bronchoalveolar lavage fluid from patients tended to have more lymphocytes and significantly more neutrophils; a lower OKT4/OKT8 ratio, due to an increase in total OKT8 cells; and normal total OKT4 cell counts, despite a significant decrease in numbers of OKT4 cells in peripheral blood. Patients also had significantly more IgG-releasing cells and higher IgG levels than controls in lavage fluid. These data show that, in the lung lining fluid of patients with the acquired immunodeficiency syndrome, significant alterations in cellular and humoral immunity exist that differ in several important respects from immunity in controls and from corresponding changes in patients' peripheral blood.",
author = "Young, {K. R.} and Rankin, {J. A.} and Naegel, {G. P.} and Paul, {E. S.} and Herbert Reynolds",
year = "1985",
month = "10",
day = "1",
language = "English (US)",
volume = "103",
pages = "522--533",
journal = "Annals of Internal Medicine",
issn = "0003-4819",
publisher = "American College of Physicians",
number = "4",

}

Bronchoalveolar lavage cells and proteins in patients with the acquired immunodeficiency syndrome. An immunologic analysis. / Young, K. R.; Rankin, J. A.; Naegel, G. P.; Paul, E. S.; Reynolds, Herbert.

In: Annals of internal medicine, Vol. 103, No. 4, 01.10.1985, p. 522-533.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bronchoalveolar lavage cells and proteins in patients with the acquired immunodeficiency syndrome. An immunologic analysis.

AU - Young, K. R.

AU - Rankin, J. A.

AU - Naegel, G. P.

AU - Paul, E. S.

AU - Reynolds, Herbert

PY - 1985/10/1

Y1 - 1985/10/1

N2 - Several components of cellular and humoral immunity were examined in bronchoalveolar lavage fluid and blood of 15 patients with the acquired immunodeficiency syndrome, and the results were compared to data from 25 healthy controls (including 5 asymptomatic homosexual men). Compared with that of controls, bronchoalveolar lavage fluid from patients tended to have more lymphocytes and significantly more neutrophils; a lower OKT4/OKT8 ratio, due to an increase in total OKT8 cells; and normal total OKT4 cell counts, despite a significant decrease in numbers of OKT4 cells in peripheral blood. Patients also had significantly more IgG-releasing cells and higher IgG levels than controls in lavage fluid. These data show that, in the lung lining fluid of patients with the acquired immunodeficiency syndrome, significant alterations in cellular and humoral immunity exist that differ in several important respects from immunity in controls and from corresponding changes in patients' peripheral blood.

AB - Several components of cellular and humoral immunity were examined in bronchoalveolar lavage fluid and blood of 15 patients with the acquired immunodeficiency syndrome, and the results were compared to data from 25 healthy controls (including 5 asymptomatic homosexual men). Compared with that of controls, bronchoalveolar lavage fluid from patients tended to have more lymphocytes and significantly more neutrophils; a lower OKT4/OKT8 ratio, due to an increase in total OKT8 cells; and normal total OKT4 cell counts, despite a significant decrease in numbers of OKT4 cells in peripheral blood. Patients also had significantly more IgG-releasing cells and higher IgG levels than controls in lavage fluid. These data show that, in the lung lining fluid of patients with the acquired immunodeficiency syndrome, significant alterations in cellular and humoral immunity exist that differ in several important respects from immunity in controls and from corresponding changes in patients' peripheral blood.

UR - http://www.scopus.com/inward/record.url?scp=0022136628&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022136628&partnerID=8YFLogxK

M3 - Article

C2 - 3876045

AN - SCOPUS:0022136628

VL - 103

SP - 522

EP - 533

JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

SN - 0003-4819

IS - 4

ER -