Building complex glycopeptides

Development of a cysteine-free native chemical ligation protocol

Bin Wu, Jiehao Chen, J. David Warren, Gong Chen, Zihao Hua, Samuel J. Danishefsky

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

(Figure Presented) The missing link: Reiterative ligations based on non-cysteine and cysteine-based acyl acceptors have been used to prepare synthetic polypeptides and proteins with multiple sites of glycosylation. Highly complex positionally defined glycopolypeptides corresponding to single glycoforms can be formed from simple components.

Original languageEnglish (US)
Pages (from-to)4116-4125
Number of pages10
JournalAngewandte Chemie - International Edition
Volume45
Issue number25
DOIs
StatePublished - Jun 19 2006

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Glycosylation
Glycopeptides
Polypeptides
Cysteine
Proteins
Peptides

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Wu, Bin ; Chen, Jiehao ; Warren, J. David ; Chen, Gong ; Hua, Zihao ; Danishefsky, Samuel J. / Building complex glycopeptides : Development of a cysteine-free native chemical ligation protocol. In: Angewandte Chemie - International Edition. 2006 ; Vol. 45, No. 25. pp. 4116-4125.
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Building complex glycopeptides : Development of a cysteine-free native chemical ligation protocol. / Wu, Bin; Chen, Jiehao; Warren, J. David; Chen, Gong; Hua, Zihao; Danishefsky, Samuel J.

In: Angewandte Chemie - International Edition, Vol. 45, No. 25, 19.06.2006, p. 4116-4125.

Research output: Contribution to journalArticle

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