Abstract
Cutaneous side effects related to vancomycin therapy have been reported including histamine-related reactions, linear IgA bullous dermatosis, Stevens-Johnson syndrome, maculopapular rash and drug rash with eosinophilia and systemic symptoms. In all instances, these reports were due to the systemic administration of vancomycin and subsequent immunological reactions to the medication. Drug extravasation into soft tissues can result in a variety of clinical outcomes usually related to physiochemical properties of the drug extravasated and its diluents or pharmacologic effects on the vasculature and tissue. The authors report a patient who experienced vancomycin extravasation that resulted in a localized bullous eruption resembling linear IgA bullous dermatosis, a phenomenon not previously described in the literature.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 177-179 |
| Number of pages | 3 |
| Journal | American Journal of the Medical Sciences |
| Volume | 343 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2012 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Bullous dermatosis associated with vancomycin extravasation. / Bohm, Nicole M.; Wong, Jeffrey G.
In: American Journal of the Medical Sciences, Vol. 343, No. 2, 02.2012, p. 177-179.Research output: Contribution to journal › Article
TY - JOUR
T1 - Bullous dermatosis associated with vancomycin extravasation
AU - Bohm, Nicole M.
AU - Wong, Jeffrey G.
PY - 2012/2
Y1 - 2012/2
N2 - Cutaneous side effects related to vancomycin therapy have been reported including histamine-related reactions, linear IgA bullous dermatosis, Stevens-Johnson syndrome, maculopapular rash and drug rash with eosinophilia and systemic symptoms. In all instances, these reports were due to the systemic administration of vancomycin and subsequent immunological reactions to the medication. Drug extravasation into soft tissues can result in a variety of clinical outcomes usually related to physiochemical properties of the drug extravasated and its diluents or pharmacologic effects on the vasculature and tissue. The authors report a patient who experienced vancomycin extravasation that resulted in a localized bullous eruption resembling linear IgA bullous dermatosis, a phenomenon not previously described in the literature.
AB - Cutaneous side effects related to vancomycin therapy have been reported including histamine-related reactions, linear IgA bullous dermatosis, Stevens-Johnson syndrome, maculopapular rash and drug rash with eosinophilia and systemic symptoms. In all instances, these reports were due to the systemic administration of vancomycin and subsequent immunological reactions to the medication. Drug extravasation into soft tissues can result in a variety of clinical outcomes usually related to physiochemical properties of the drug extravasated and its diluents or pharmacologic effects on the vasculature and tissue. The authors report a patient who experienced vancomycin extravasation that resulted in a localized bullous eruption resembling linear IgA bullous dermatosis, a phenomenon not previously described in the literature.
UR - http://www.scopus.com/inward/record.url?scp=84856680142&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856680142&partnerID=8YFLogxK
U2 - 10.1097/MAJ.0b013e318237bb47
DO - 10.1097/MAJ.0b013e318237bb47
M3 - Article
C2 - 22104428
AN - SCOPUS:84856680142
VL - 343
SP - 177
EP - 179
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
SN - 0002-9629
IS - 2
ER -