Butryic acid analogues augment γ globin gene expression in neonatal erythroid progenitors

S. P. Perrine, B. A. Miller, M. F. Greene, R. A. Cohen, N. Cook, C. Shackleton, D. V. Faller

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The γ→β globin gene switch in humans is normally on a set developmental clock but is delayed in infants of diabetic mothers. We cultured cord blood erythroid progenitors and assayed globin produced in the presence and absence of metabolites that are elevated in such infants. Analogues of butyric acid at supranormal concentrations significantly augmented γ and inhibited β globin expression. The uptake of α-amino-n-butyric acid into colony-derived erythroblasts was increased in the presence of supranormal insulin. These findings suggest that elevated levels of α-amino-n-butyric acid and insulin in the developing fetus delay the globin switch and may offer potential for augmenting γ globin expression in the β globin chain diseases.

Original languageEnglish (US)
Pages (from-to)694-700
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume148
Issue number2
DOIs
StatePublished - Oct 29 1987

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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