Bystander Selection for Antimicrobial Resistance: Implications for Patient Health

Valerie J. Morley, Robert J. Woods, Andrew F. Read

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Antimicrobial therapy promotes resistance emergence in target infections and in off-target microbiota. Off-target resistance emergence threatens patient health when off-target populations are a source of future infections, as they are for many important drug-resistant pathogens. However, the health risks of antimicrobial exposure in off-target populations remain largely unquantified, making rational antibiotic stewardship challenging. Here, we discuss the contribution of bystander antimicrobial exposure to the resistance crisis, the implications for antimicrobial stewardship, and some novel opportunities to limit resistance evolution while treating target pathogens.

Original languageEnglish (US)
Pages (from-to)864-877
Number of pages14
JournalTrends in Microbiology
Volume27
Issue number10
DOIs
StatePublished - Oct 2019

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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