C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection

Jianxun Song, Mohammad Haque, Jianyong Song, Kristin Fino, Youfei Wang, Praneet Sandhu, Xinmeng Song, Christopher Norbury, Bing Ni, Deyu Fang, Shahram Salek-Ardakani

Research output: Contribution to journalArticle

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Abstract

The signalling mechanisms of costimulation in the development of memory T cells remain to be clarified. Here, we show that the transcription factor c-Myc in CD8+ T cells is controlled by costimulatory molecules, which modulates the development of memory CD8+ T cells. C-Myc expression was dramatically reduced in Cd28-/- or Ox40-/- memory CD8+ T cells, and c-Myc over-expression substantially reversed the defects in the development of T-cell memory following viral infection. C-Myc regulated the expression of survivin, an inhibitor of apoptosis, which promoted the generation of virus-specific memory CD8+ T cells. Moreover, over-expression of survivin with bcl-xL, a downstream molecule of NF-κB and intracellular target of costimulation that controls survival, in Cd28-/- or Ox40-/- CD8+ T cells, reversed the defects in the generation of memory T cells in response to viral infection. These results identify c-Myc as a key controller of memory CD8+ T cells from costimulatory signals.

Original languageEnglish (US)
Article number150208
JournalOpen biology
Volume6
Issue number1
DOIs
StatePublished - Jan 2016

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T-cells
Virus Diseases
T-Lymphocytes
Data storage equipment
Defects
Molecules
Viruses
Transcription Factors
Apoptosis
Controllers

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Song, J., Haque, M., Song, J., Fino, K., Wang, Y., Sandhu, P., ... Salek-Ardakani, S. (2016). C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection. Open biology, 6(1), [150208]. https://doi.org/10.1098/rsob.150208
Song, Jianxun ; Haque, Mohammad ; Song, Jianyong ; Fino, Kristin ; Wang, Youfei ; Sandhu, Praneet ; Song, Xinmeng ; Norbury, Christopher ; Ni, Bing ; Fang, Deyu ; Salek-Ardakani, Shahram. / C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection. In: Open biology. 2016 ; Vol. 6, No. 1.
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abstract = "The signalling mechanisms of costimulation in the development of memory T cells remain to be clarified. Here, we show that the transcription factor c-Myc in CD8+ T cells is controlled by costimulatory molecules, which modulates the development of memory CD8+ T cells. C-Myc expression was dramatically reduced in Cd28-/- or Ox40-/- memory CD8+ T cells, and c-Myc over-expression substantially reversed the defects in the development of T-cell memory following viral infection. C-Myc regulated the expression of survivin, an inhibitor of apoptosis, which promoted the generation of virus-specific memory CD8+ T cells. Moreover, over-expression of survivin with bcl-xL, a downstream molecule of NF-κB and intracellular target of costimulation that controls survival, in Cd28-/- or Ox40-/- CD8+ T cells, reversed the defects in the generation of memory T cells in response to viral infection. These results identify c-Myc as a key controller of memory CD8+ T cells from costimulatory signals.",
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Song, J, Haque, M, Song, J, Fino, K, Wang, Y, Sandhu, P, Song, X, Norbury, C, Ni, B, Fang, D & Salek-Ardakani, S 2016, 'C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection', Open biology, vol. 6, no. 1, 150208. https://doi.org/10.1098/rsob.150208

C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection. / Song, Jianxun; Haque, Mohammad; Song, Jianyong; Fino, Kristin; Wang, Youfei; Sandhu, Praneet; Song, Xinmeng; Norbury, Christopher; Ni, Bing; Fang, Deyu; Salek-Ardakani, Shahram.

In: Open biology, Vol. 6, No. 1, 150208, 01.2016.

Research output: Contribution to journalArticle

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AU - Haque, Mohammad

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AU - Wang, Youfei

AU - Sandhu, Praneet

AU - Song, Xinmeng

AU - Norbury, Christopher

AU - Ni, Bing

AU - Fang, Deyu

AU - Salek-Ardakani, Shahram

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