Abstract
The authors prospectively examined whether caffeine intake was associated with lower risk of Parkinson disease (PD) in both men and women among 304,980 participants in the National Institutes of Health-AARP Diet and Health Study and whether smoking affected this relation. Multivariate odds ratios and 95% confidence intervals were derived from logistic regression models. Higher caffeine intake as assessed in 19951996 was monotonically associated with lower PD risk (diagnosed in 20002006) in both men and women. After adjustment for age, race, and physical activity, the odds ratio comparing the highest quintile of caffeine intake with the lowest was 0.75 (95% confidence interval: 0.60, 0.94; P trend 0.005) for men and 0.60 (95% confidence interval: 0.39, 0.91; P trend 0.005) for women. Further adjustment for duration of smoking and analyses carried out among never smokers showed similar results. A joint analysis with smoking suggested that smoking and caffeine may act independently in relation to PD risk. Finally, the authors conducted a meta-analysis of prospective studies and confirmed that caffeine intake was inversely associated with PD risk in both men and women. These findings suggest no gender difference in the relation between caffeine and PD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1200-1207 |
| Number of pages | 8 |
| Journal | American journal of epidemiology |
| Volume | 175 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jun 1 2012 |
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All Science Journal Classification (ASJC) codes
- Epidemiology
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Caffeine intake, smoking, and risk of parkinson disease in men and women. / Liu, Rui; Guo, Xuguang; Park, Yikyung; Huang, Xuemei; Sinha, Rashmi; Freedman, Neal D.; Hollenbeck, Albert R.; Blair, Aaron; Chen, Honglei.
In: American journal of epidemiology, Vol. 175, No. 11, 01.06.2012, p. 1200-1207.Research output: Contribution to journal › Article
TY - JOUR
T1 - Caffeine intake, smoking, and risk of parkinson disease in men and women
AU - Liu, Rui
AU - Guo, Xuguang
AU - Park, Yikyung
AU - Huang, Xuemei
AU - Sinha, Rashmi
AU - Freedman, Neal D.
AU - Hollenbeck, Albert R.
AU - Blair, Aaron
AU - Chen, Honglei
PY - 2012/6/1
Y1 - 2012/6/1
N2 - The authors prospectively examined whether caffeine intake was associated with lower risk of Parkinson disease (PD) in both men and women among 304,980 participants in the National Institutes of Health-AARP Diet and Health Study and whether smoking affected this relation. Multivariate odds ratios and 95% confidence intervals were derived from logistic regression models. Higher caffeine intake as assessed in 19951996 was monotonically associated with lower PD risk (diagnosed in 20002006) in both men and women. After adjustment for age, race, and physical activity, the odds ratio comparing the highest quintile of caffeine intake with the lowest was 0.75 (95% confidence interval: 0.60, 0.94; P trend 0.005) for men and 0.60 (95% confidence interval: 0.39, 0.91; P trend 0.005) for women. Further adjustment for duration of smoking and analyses carried out among never smokers showed similar results. A joint analysis with smoking suggested that smoking and caffeine may act independently in relation to PD risk. Finally, the authors conducted a meta-analysis of prospective studies and confirmed that caffeine intake was inversely associated with PD risk in both men and women. These findings suggest no gender difference in the relation between caffeine and PD.
AB - The authors prospectively examined whether caffeine intake was associated with lower risk of Parkinson disease (PD) in both men and women among 304,980 participants in the National Institutes of Health-AARP Diet and Health Study and whether smoking affected this relation. Multivariate odds ratios and 95% confidence intervals were derived from logistic regression models. Higher caffeine intake as assessed in 19951996 was monotonically associated with lower PD risk (diagnosed in 20002006) in both men and women. After adjustment for age, race, and physical activity, the odds ratio comparing the highest quintile of caffeine intake with the lowest was 0.75 (95% confidence interval: 0.60, 0.94; P trend 0.005) for men and 0.60 (95% confidence interval: 0.39, 0.91; P trend 0.005) for women. Further adjustment for duration of smoking and analyses carried out among never smokers showed similar results. A joint analysis with smoking suggested that smoking and caffeine may act independently in relation to PD risk. Finally, the authors conducted a meta-analysis of prospective studies and confirmed that caffeine intake was inversely associated with PD risk in both men and women. These findings suggest no gender difference in the relation between caffeine and PD.
UR - http://www.scopus.com/inward/record.url?scp=84862202565&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862202565&partnerID=8YFLogxK
U2 - 10.1093/aje/kwr451
DO - 10.1093/aje/kwr451
M3 - Article
C2 - 22505763
AN - SCOPUS:84862202565
VL - 175
SP - 1200
EP - 1207
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 11
ER -