Calcification inside artificial hearts: Inhibition by warfarin-sodium

William S. Pierce, James H. Donachy, Gerson Rosenberg, Robert E. Baier

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Intracavitary calcium phosphate deposits were observed in smooth, elastomeric blood pump sacs implanted in male calves for periods of 115 to 166 days. These deposits occurred predominantly on the flexing surface of the sacs. In contrast, similar pump sacs remained generally free of mineral deposits for up to 150 days in calves treated with the anticoagulant warfarin-sodium. These results implicate a vitamin K-dependent process in calcium phosphate deposition on elastomeric sacs.

Original languageEnglish (US)
Pages (from-to)601-603
Number of pages3
JournalScience
Volume208
Issue number4444
DOIs
StatePublished - Jan 1 1980

    Fingerprint

All Science Journal Classification (ASJC) codes

  • General

Cite this