Calcitonin depresses amphetamine-induced locomotor activity

Michael J. Twery; Cary W. Cooper; Richard Mailman

doi:10.1016/S0091-3057(83)80005-7

Calcitonin depresses amphetamine-induced locomotor activity

Michael J. Twery, Cary W. Cooper, Richard Mailman

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Synthetic salmon calcitonin (sCT), given subcutaneously (6.4 g/kg) or intracerebroventricularly (ICV, 30-600 ng), depressed amphetamine-induced locomotor activity in rats by more than 50%. ICV injection of sCT, either three hours or immediately before intraperitoneal amphetamine (1-3 mg/kg), significantly reduced the amphetamine-induced activity. In the absence of amphetamine, sCT had no effect on locomotor activity during the first 100 minutes after treatment. These results show sCT can act centrally to modify drug-induced behavior and may be related to reports of calcitonin receptors and calcitonin-like peptides in the brain.

Original language	English (US)
Pages (from-to)	857-862
Number of pages	6
Journal	Pharmacology, Biochemistry and Behavior
Volume	18
Issue number	6
DOIs	https://doi.org/10.1016/S0091-3057(83)80005-7
State	Published - 1983

All Science Journal Classification (ASJC) codes

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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title = "Calcitonin depresses amphetamine-induced locomotor activity",

abstract = "Synthetic salmon calcitonin (sCT), given subcutaneously (6.4 g/kg) or intracerebroventricularly (ICV, 30-600 ng), depressed amphetamine-induced locomotor activity in rats by more than 50%. ICV injection of sCT, either three hours or immediately before intraperitoneal amphetamine (1-3 mg/kg), significantly reduced the amphetamine-induced activity. In the absence of amphetamine, sCT had no effect on locomotor activity during the first 100 minutes after treatment. These results show sCT can act centrally to modify drug-induced behavior and may be related to reports of calcitonin receptors and calcitonin-like peptides in the brain.",

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AU - Cooper, Cary W.

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AB - Synthetic salmon calcitonin (sCT), given subcutaneously (6.4 g/kg) or intracerebroventricularly (ICV, 30-600 ng), depressed amphetamine-induced locomotor activity in rats by more than 50%. ICV injection of sCT, either three hours or immediately before intraperitoneal amphetamine (1-3 mg/kg), significantly reduced the amphetamine-induced activity. In the absence of amphetamine, sCT had no effect on locomotor activity during the first 100 minutes after treatment. These results show sCT can act centrally to modify drug-induced behavior and may be related to reports of calcitonin receptors and calcitonin-like peptides in the brain.

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