TY - JOUR
T1 - Calcitonin depresses amphetamine-induced locomotor activity
AU - Twery, Michael J.
AU - Cooper, Cary W.
AU - Mailman, Richard
N1 - Funding Information:
Synthetic sCT (4700 MRC U/mg) was a gift from Armour Pharmaceutical Co. (Kankakee, IL) and was dissolved in 1 mM HCI:0.15 M NaCI for injection. For SC administration, sCT was injected in a volume of 1 ml/kg body weight. All doses of sCT administered ICV were delivered as a bolus 'Supported by USPHS Grants AM-17743 and AM-32060 from the NIADDK. ~Portions of this work were presented at the 12th Annual Society for Neuroscience meeting, November 2, 1982. :~Present address: Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77550.
PY - 1983
Y1 - 1983
N2 - Synthetic salmon calcitonin (sCT), given subcutaneously (6.4 g/kg) or intracerebroventricularly (ICV, 30-600 ng), depressed amphetamine-induced locomotor activity in rats by more than 50%. ICV injection of sCT, either three hours or immediately before intraperitoneal amphetamine (1-3 mg/kg), significantly reduced the amphetamine-induced activity. In the absence of amphetamine, sCT had no effect on locomotor activity during the first 100 minutes after treatment. These results show sCT can act centrally to modify drug-induced behavior and may be related to reports of calcitonin receptors and calcitonin-like peptides in the brain.
AB - Synthetic salmon calcitonin (sCT), given subcutaneously (6.4 g/kg) or intracerebroventricularly (ICV, 30-600 ng), depressed amphetamine-induced locomotor activity in rats by more than 50%. ICV injection of sCT, either three hours or immediately before intraperitoneal amphetamine (1-3 mg/kg), significantly reduced the amphetamine-induced activity. In the absence of amphetamine, sCT had no effect on locomotor activity during the first 100 minutes after treatment. These results show sCT can act centrally to modify drug-induced behavior and may be related to reports of calcitonin receptors and calcitonin-like peptides in the brain.
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U2 - 10.1016/S0091-3057(83)80005-7
DO - 10.1016/S0091-3057(83)80005-7
M3 - Article
C2 - 6889413
AN - SCOPUS:0020614193
VL - 18
SP - 857
EP - 862
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 6
ER -