Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer Cells

Mark Kester, Yasser Heakal, Todd Fox, Arati Sharma, Gavin P. Robertson, Thomas T. Morgan, Erhan I. Altinoǧlu, Amra Tabaković, Mylisa R. Parette, Sarah M. Rouse, Victor Ruiz-Velasco, James H. Adair

Research output: Contribution to journalArticlepeer-review

219 Scopus citations

Abstract

Paradigm-shifting modalities to more efficiently deliver drugs to cancerous lesions require the following attributes: nanoscale-size, targetability, and stability under physiological conditions. Often, these nanoscale drug delivery vehicles are limited due to agglomeration, poor solubility, or cytotoxicity. Thus, we have designed a methodology to encapsulate hydrophobic antineoplastic chemotherapeutics within a 20-30 nm diameter, pH-responsive, nonagglomerating, nontoxic calcium phosphate nanoparticle matrix. In the present study, we report on calcium phosphate nanocomposite particles (CPNPs) that encapsulate both fluorophores and chemotherapeutics, are colloidally stable in physiological solution for an extended time at 37 °C and can efficaciously deliver hydrophobic antineoplastic agents, such as ceramide, in several cell model systems.

Original languageEnglish (US)
Pages (from-to)4116-4121
Number of pages6
JournalNano letters
Volume8
Issue number12
DOIs
StatePublished - Dec 2008

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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