Calcium signalling in T cells

Mohamed Trebak, Jean Pierre Kinet

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Calcium (Ca 2+ ) signalling is of paramount importance to immunity. Regulated increases in cytosolic and organellar Ca 2+ concentrations in lymphocytes control complex and crucial effector functions such as metabolism, proliferation, differentiation, antibody and cytokine secretion and cytotoxicity. Altered Ca 2+ regulation in lymphocytes leads to various autoimmune, inflammatory and immunodeficiency syndromes. Several types of plasma membrane and organellar Ca 2+ -permeable channels are functional in T cells. They contribute highly localized spatial and temporal Ca 2+ microdomains that are required for achieving functional specificity. While the mechanistic details of these Ca 2+ microdomains are only beginning to emerge, it is evident that through crosstalk, synergy and feedback mechanisms, they fine-tune T cell signalling to match complex immune responses. In this article, we review the expression and function of various Ca 2+ -permeable channels in the plasma membrane, endoplasmic reticulum, mitochondria and endolysosomes of T cells and their role in shaping immunity and the pathogenesis of immune-mediated diseases.

Original languageEnglish (US)
Pages (from-to)154-169
Number of pages16
JournalNature Reviews Immunology
Volume19
Issue number3
DOIs
StatePublished - Mar 1 2019

Fingerprint

Calcium Signaling
T-Lymphocytes
Immunity
Cell Membrane
Lymphocytes
Immune System Diseases
Antigen-Antibody Complex
Endoplasmic Reticulum
Mitochondria
Cytokines
Calcium
Antibodies

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Trebak, Mohamed ; Kinet, Jean Pierre. / Calcium signalling in T cells. In: Nature Reviews Immunology. 2019 ; Vol. 19, No. 3. pp. 154-169.
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Calcium signalling in T cells. / Trebak, Mohamed; Kinet, Jean Pierre.

In: Nature Reviews Immunology, Vol. 19, No. 3, 01.03.2019, p. 154-169.

Research output: Contribution to journalReview article

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