Calcium Signals: STIM Dynamics Mediate Spatially Unique Oscillations

Salvatore Mancarella, Youjun Wang, Donald L. Gill

Research output: Contribution to journalShort surveypeer-review

14 Scopus citations

Abstract

Receptor-induced Ca2+ oscillations provide 'digitized' signals that confer precise activation of downstream targets. New studies reveal that STIM proteins - sensors of endoplasmic reticulum Ca2+ levels - cyclically translocate during oscillations, transiently coupling to activate cell-surface Ca2+ entry channels, resulting in a spatially unique signal that selectively triggers immediate-early gene expression.

Original languageEnglish (US)
Pages (from-to)R950-R952
JournalCurrent Biology
Volume19
Issue number20
DOIs
StatePublished - Nov 3 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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