Receptor-induced Ca2+ oscillations provide 'digitized' signals that confer precise activation of downstream targets. New studies reveal that STIM proteins - sensors of endoplasmic reticulum Ca2+ levels - cyclically translocate during oscillations, transiently coupling to activate cell-surface Ca2+ entry channels, resulting in a spatially unique signal that selectively triggers immediate-early gene expression.
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)