Abstract
To evaluate the effect of calcium supplementation on bone acquisition in adolescent white girls. A randomized, double-blind, placebo-controlled trial of the effect of 18 months of calcium supplementation on bone density and bone mass. Ninety-four girls with a mean age of 11.9+0.5 years at study entry. University hospital in a small town. Calcium supplementation, 500 mg/d calcium as calcium citrate malate; controls received placebo pills. Bone mineral density and bone mineral content of the lumbar spine and total body were measured by dual-energy x-ray absorptiometry and calcium excretion from 24-hour urine specimens. Calcium intake from dietary sources averaged 960 mg/d for the entire study group. The supplemented group received, on average, an additional 354 mg/d of calcium. The supplemented group compared with the placebo group had greater increases of lumbar spine bone density (18.7% vs 15.8%; P=.03), lumbar spine bone mineral content (39.4% vs 34.7%; P=.06), total body bone mineral density (9.6% vs 8.3%; P=.05), and 24-hour urinary calcium excretion (90.4 vs 72.9 mg/d; P=.02), respectively. Increasing daily calcium intake from 80% of the recommended daily allowance to 110% via supplementation with calcium citrate malate resulted in significant increases in total body and spinal bone density in adolescent girls. The increase of 24 g of bone gain per year among the supplemented group translates to an additional 1.3% skeletal mass per year during adolescent growth, which may provide protection against future osteoporotic fracture.
Original language | English (US) |
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Pages (from-to) | 841-844 |
Number of pages | 4 |
Journal | JAMA: The Journal of the American Medical Association |
Volume | 270 |
Issue number | 7 |
DOIs | |
State | Published - Aug 18 1993 |
All Science Journal Classification (ASJC) codes
- Medicine(all)