Calf Muscle Oxygen Saturation during 6-Minute Walk Test and Its Relationship with Walking Impairment in Symptomatic Peripheral Artery Disease

Aluísio Andrade-Lima, Gabriel G. Cucato, Wagner J.R. Domingues, Antônio H. Germano-Soares, Bruno R. Cavalcante, Marilia A. Correia, Glauco F. Saes, Nelson Wolosker, Andrew Gardner, Antônio E. Zerati, Raphael M. Ritti-Dias

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Impaired microcirculation is associated with poor walking capacity in symptomatic peripheral artery disease (PAD) patients during treadmill test; however, this test does not simulate the efforts of daily walking of these patients. Thus, the aim of the study was to describe the microcirculation responses during a 6-minute walk test (6MWT) and to analyze the relationship between microcirculation indicators and walking impairment in symptomatic PAD patients. Methods: Thirty-four patients were included (mean age = 67.6 ± 11.2 years). Their clinical characteristics were collected, and they performed a 6MWT, in which the initial claudication distance (ICD) and total walking distance (TWD) were recorded. During and after the 6MWT, calf muscle oxygen saturation (StO2) parameters were monitored continuously to measure microcirculation behavior. The association between calf muscle StO2 parameters and walking impairment were analyzed by Pearson or Spearman correlations. Results: Walking impairment was not associated with any StO2 parameters during exercise. In contrast, after 6MWT, recovery time of StO2 (r = −0.472, P = 0.008) and recovery time to maximal StO2 (r = −0.402, P = 0.019) were negatively correlated with ICD. Furthermore, the distance walked under claudication symptoms (ΔTWD–ICD) was positively correlated with recovery time to maximal StO2 (r = 0.347, P = 0.048). Conclusions: In symptomatic PAD patients, shorter ICD values during a 6MWT are associated with a delayed recovery in calf muscle StO2 after exercise. Calf muscle StO2 parameters decrease subtly during 6MWT, suggesting that the degree of ischemia in the calf muscle during ground walking, simulating efforts of the daily walking, is relatively low.

Original languageEnglish (US)
JournalAnnals of Vascular Surgery
DOIs
StateAccepted/In press - Jan 1 2018

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Peripheral Arterial Disease
Walking
Oxygen
Muscles
Microcirculation
Exercise
Walk Test
Exercise Test
Ischemia

All Science Journal Classification (ASJC) codes

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Andrade-Lima, A., Cucato, G. G., Domingues, W. J. R., Germano-Soares, A. H., Cavalcante, B. R., Correia, M. A., ... Ritti-Dias, R. M. (Accepted/In press). Calf Muscle Oxygen Saturation during 6-Minute Walk Test and Its Relationship with Walking Impairment in Symptomatic Peripheral Artery Disease. Annals of Vascular Surgery. https://doi.org/10.1016/j.avsg.2018.03.038
Andrade-Lima, Aluísio ; Cucato, Gabriel G. ; Domingues, Wagner J.R. ; Germano-Soares, Antônio H. ; Cavalcante, Bruno R. ; Correia, Marilia A. ; Saes, Glauco F. ; Wolosker, Nelson ; Gardner, Andrew ; Zerati, Antônio E. ; Ritti-Dias, Raphael M. / Calf Muscle Oxygen Saturation during 6-Minute Walk Test and Its Relationship with Walking Impairment in Symptomatic Peripheral Artery Disease. In: Annals of Vascular Surgery. 2018.
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title = "Calf Muscle Oxygen Saturation during 6-Minute Walk Test and Its Relationship with Walking Impairment in Symptomatic Peripheral Artery Disease",
abstract = "Background: Impaired microcirculation is associated with poor walking capacity in symptomatic peripheral artery disease (PAD) patients during treadmill test; however, this test does not simulate the efforts of daily walking of these patients. Thus, the aim of the study was to describe the microcirculation responses during a 6-minute walk test (6MWT) and to analyze the relationship between microcirculation indicators and walking impairment in symptomatic PAD patients. Methods: Thirty-four patients were included (mean age = 67.6 ± 11.2 years). Their clinical characteristics were collected, and they performed a 6MWT, in which the initial claudication distance (ICD) and total walking distance (TWD) were recorded. During and after the 6MWT, calf muscle oxygen saturation (StO2) parameters were monitored continuously to measure microcirculation behavior. The association between calf muscle StO2 parameters and walking impairment were analyzed by Pearson or Spearman correlations. Results: Walking impairment was not associated with any StO2 parameters during exercise. In contrast, after 6MWT, recovery time of StO2 (r = −0.472, P = 0.008) and recovery time to maximal StO2 (r = −0.402, P = 0.019) were negatively correlated with ICD. Furthermore, the distance walked under claudication symptoms (ΔTWD–ICD) was positively correlated with recovery time to maximal StO2 (r = 0.347, P = 0.048). Conclusions: In symptomatic PAD patients, shorter ICD values during a 6MWT are associated with a delayed recovery in calf muscle StO2 after exercise. Calf muscle StO2 parameters decrease subtly during 6MWT, suggesting that the degree of ischemia in the calf muscle during ground walking, simulating efforts of the daily walking, is relatively low.",
author = "Alu{\'i}sio Andrade-Lima and Cucato, {Gabriel G.} and Domingues, {Wagner J.R.} and Germano-Soares, {Ant{\^o}nio H.} and Cavalcante, {Bruno R.} and Correia, {Marilia A.} and Saes, {Glauco F.} and Nelson Wolosker and Andrew Gardner and Zerati, {Ant{\^o}nio E.} and Ritti-Dias, {Raphael M.}",
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Andrade-Lima, A, Cucato, GG, Domingues, WJR, Germano-Soares, AH, Cavalcante, BR, Correia, MA, Saes, GF, Wolosker, N, Gardner, A, Zerati, AE & Ritti-Dias, RM 2018, 'Calf Muscle Oxygen Saturation during 6-Minute Walk Test and Its Relationship with Walking Impairment in Symptomatic Peripheral Artery Disease', Annals of Vascular Surgery. https://doi.org/10.1016/j.avsg.2018.03.038

Calf Muscle Oxygen Saturation during 6-Minute Walk Test and Its Relationship with Walking Impairment in Symptomatic Peripheral Artery Disease. / Andrade-Lima, Aluísio; Cucato, Gabriel G.; Domingues, Wagner J.R.; Germano-Soares, Antônio H.; Cavalcante, Bruno R.; Correia, Marilia A.; Saes, Glauco F.; Wolosker, Nelson; Gardner, Andrew; Zerati, Antônio E.; Ritti-Dias, Raphael M.

In: Annals of Vascular Surgery, 01.01.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Calf Muscle Oxygen Saturation during 6-Minute Walk Test and Its Relationship with Walking Impairment in Symptomatic Peripheral Artery Disease

AU - Andrade-Lima, Aluísio

AU - Cucato, Gabriel G.

AU - Domingues, Wagner J.R.

AU - Germano-Soares, Antônio H.

AU - Cavalcante, Bruno R.

AU - Correia, Marilia A.

AU - Saes, Glauco F.

AU - Wolosker, Nelson

AU - Gardner, Andrew

AU - Zerati, Antônio E.

AU - Ritti-Dias, Raphael M.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Impaired microcirculation is associated with poor walking capacity in symptomatic peripheral artery disease (PAD) patients during treadmill test; however, this test does not simulate the efforts of daily walking of these patients. Thus, the aim of the study was to describe the microcirculation responses during a 6-minute walk test (6MWT) and to analyze the relationship between microcirculation indicators and walking impairment in symptomatic PAD patients. Methods: Thirty-four patients were included (mean age = 67.6 ± 11.2 years). Their clinical characteristics were collected, and they performed a 6MWT, in which the initial claudication distance (ICD) and total walking distance (TWD) were recorded. During and after the 6MWT, calf muscle oxygen saturation (StO2) parameters were monitored continuously to measure microcirculation behavior. The association between calf muscle StO2 parameters and walking impairment were analyzed by Pearson or Spearman correlations. Results: Walking impairment was not associated with any StO2 parameters during exercise. In contrast, after 6MWT, recovery time of StO2 (r = −0.472, P = 0.008) and recovery time to maximal StO2 (r = −0.402, P = 0.019) were negatively correlated with ICD. Furthermore, the distance walked under claudication symptoms (ΔTWD–ICD) was positively correlated with recovery time to maximal StO2 (r = 0.347, P = 0.048). Conclusions: In symptomatic PAD patients, shorter ICD values during a 6MWT are associated with a delayed recovery in calf muscle StO2 after exercise. Calf muscle StO2 parameters decrease subtly during 6MWT, suggesting that the degree of ischemia in the calf muscle during ground walking, simulating efforts of the daily walking, is relatively low.

AB - Background: Impaired microcirculation is associated with poor walking capacity in symptomatic peripheral artery disease (PAD) patients during treadmill test; however, this test does not simulate the efforts of daily walking of these patients. Thus, the aim of the study was to describe the microcirculation responses during a 6-minute walk test (6MWT) and to analyze the relationship between microcirculation indicators and walking impairment in symptomatic PAD patients. Methods: Thirty-four patients were included (mean age = 67.6 ± 11.2 years). Their clinical characteristics were collected, and they performed a 6MWT, in which the initial claudication distance (ICD) and total walking distance (TWD) were recorded. During and after the 6MWT, calf muscle oxygen saturation (StO2) parameters were monitored continuously to measure microcirculation behavior. The association between calf muscle StO2 parameters and walking impairment were analyzed by Pearson or Spearman correlations. Results: Walking impairment was not associated with any StO2 parameters during exercise. In contrast, after 6MWT, recovery time of StO2 (r = −0.472, P = 0.008) and recovery time to maximal StO2 (r = −0.402, P = 0.019) were negatively correlated with ICD. Furthermore, the distance walked under claudication symptoms (ΔTWD–ICD) was positively correlated with recovery time to maximal StO2 (r = 0.347, P = 0.048). Conclusions: In symptomatic PAD patients, shorter ICD values during a 6MWT are associated with a delayed recovery in calf muscle StO2 after exercise. Calf muscle StO2 parameters decrease subtly during 6MWT, suggesting that the degree of ischemia in the calf muscle during ground walking, simulating efforts of the daily walking, is relatively low.

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