Can resistance against quorum-sensing interference be selected?

Rodolfo Garcia-Contreras, Toshinari Maeda, Thomas K. Wood

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Quorum-sensing (QS) interference is a novel therapy to fight bacterial infections that, unlike conventional antibiotic treatments, is focused on reducing the damage caused by pathogens (virulence) rather than focused on inhibiting their growth. Given this ideal, it was predicted that this approach will be impervious to or at least much less prone to resistance in bacterial populations. However, recently, resistance mechanisms against well-characterized quorum quenchers (QQs) have been found in the laboratory as well as in clinical strains, demonstrating that the rise of resistance against these kinds of compounds is possible. Nevertheless, it has been argued that even if resistance mechanisms against QS interference exist, this fact does not guarantee that resistance will spread. In the present work, we discuss recent insights derived from the latest experiments to address this question. In addition, we explain how environmental conditions like the stress produced by the host immune system may influence the selection of resistance and eventually lead to the selection of QS interference-resistant bacteria in a clinical setting.

Original languageEnglish (US)
Pages (from-to)4-10
Number of pages7
JournalISME Journal
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Quorum Sensing
quorum sensing
crossover interference
resistance mechanisms
immune system
virulence
antibiotics
pathogen
environmental conditions
bacterial infections
Bacterial Infections
damage
bacterium
Virulence
Immune System
Anti-Bacterial Agents
Bacteria
therapeutics
environmental factors
pathogens

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Garcia-Contreras, Rodolfo ; Maeda, Toshinari ; Wood, Thomas K. / Can resistance against quorum-sensing interference be selected?. In: ISME Journal. 2016 ; Vol. 10, No. 1. pp. 4-10.
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Can resistance against quorum-sensing interference be selected? / Garcia-Contreras, Rodolfo; Maeda, Toshinari; Wood, Thomas K.

In: ISME Journal, Vol. 10, No. 1, 01.01.2016, p. 4-10.

Research output: Contribution to journalReview article

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