Cancer and Parkinson's disease

The odd couple

Xiang Gao, Y. Ning

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Epidemiological studies have consistently shown that individuals with Parkinson's disease (PD) are less likely to develop nonmelanoma cancers and vice versa. In contrast, the co-occurrence of PD and melanoma has been reported in numerous studies. The exact mechanisms underlying the observed cancer - PD association are not clear. Different hypotheses have been put forward, including shared environmental/lifestyle factors (e.g., smoking and socioeconomic status) and common genetic components (e.g., parkinson protein 2 [PARK2], leucine-rich repeat kinase 2 [LRRK2], Parkinson disease [autosomal recessive, early onset] 7 [PARK7, DJ-1] and pigmentation genes). In the current review, we summarize recent findings to offer new insight into the pathogenesis of both conditions.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalDrugs of Today
Volume47
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Parkinson Disease
Neoplasms
Pigmentation
Social Class
Life Style
Epidemiologic Studies
Melanoma
Phosphotransferases
Smoking
Genes
Autosomal Recessive Early-Onset Parkinson Disease 7
leucine-rich repeat proteins

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Medicine(all)

Cite this

Gao, Xiang ; Ning, Y. / Cancer and Parkinson's disease : The odd couple. In: Drugs of Today. 2011 ; Vol. 47, No. 3. pp. 215-222.
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Cancer and Parkinson's disease : The odd couple. / Gao, Xiang; Ning, Y.

In: Drugs of Today, Vol. 47, No. 3, 03.2011, p. 215-222.

Research output: Contribution to journalReview article

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