Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration

Shuso Takeda, Shunsuke Okajima, Hiroko Miyoshi, Kazutaka Yoshida, Yoshiko Okamoto, Tomoko Okada, Toshiaki Amamoto, Kazuhito Watanabe, Curtis John Omiecinski, Hironori Aramaki

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, has been reported to possess diverse biological activities, including anti-proliferative effect on cancer cells. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), few studies have investigated whether CBDA itself is biologically active. Results of the current investigation revealed that CBDA inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. It is established that activation of the RhoA signaling pathway leads to inhibition of the mobility of various cancer cells, including MDA-MB-231 cells. The data presented in this report suggest for the first time that as an active component in the cannabis plant, CBDA offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers.

Original languageEnglish (US)
Pages (from-to)314-319
Number of pages6
JournalToxicology Letters
Volume214
Issue number3
DOIs
StatePublished - Nov 15 2012

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Cannabinoids
Cannabis
Cell Movement
Cells
Cannabidiol
Breast Neoplasms
Fibers
Cyclic AMP-Dependent Protein Kinases
Chemical activation
Neoplasms
Decarboxylation
Monomeric GTP-Binding Proteins
Bioactivity
Molecules
cannabidiolic acid
Therapeutics

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Takeda, Shuso ; Okajima, Shunsuke ; Miyoshi, Hiroko ; Yoshida, Kazutaka ; Okamoto, Yoshiko ; Okada, Tomoko ; Amamoto, Toshiaki ; Watanabe, Kazuhito ; Omiecinski, Curtis John ; Aramaki, Hironori. / Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. In: Toxicology Letters. 2012 ; Vol. 214, No. 3. pp. 314-319.
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abstract = "Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, has been reported to possess diverse biological activities, including anti-proliferative effect on cancer cells. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), few studies have investigated whether CBDA itself is biologically active. Results of the current investigation revealed that CBDA inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. It is established that activation of the RhoA signaling pathway leads to inhibition of the mobility of various cancer cells, including MDA-MB-231 cells. The data presented in this report suggest for the first time that as an active component in the cannabis plant, CBDA offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers.",
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Takeda, S, Okajima, S, Miyoshi, H, Yoshida, K, Okamoto, Y, Okada, T, Amamoto, T, Watanabe, K, Omiecinski, CJ & Aramaki, H 2012, 'Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration', Toxicology Letters, vol. 214, no. 3, pp. 314-319. https://doi.org/10.1016/j.toxlet.2012.08.029

Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. / Takeda, Shuso; Okajima, Shunsuke; Miyoshi, Hiroko; Yoshida, Kazutaka; Okamoto, Yoshiko; Okada, Tomoko; Amamoto, Toshiaki; Watanabe, Kazuhito; Omiecinski, Curtis John; Aramaki, Hironori.

In: Toxicology Letters, Vol. 214, No. 3, 15.11.2012, p. 314-319.

Research output: Contribution to journalArticle

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AU - Takeda, Shuso

AU - Okajima, Shunsuke

AU - Miyoshi, Hiroko

AU - Yoshida, Kazutaka

AU - Okamoto, Yoshiko

AU - Okada, Tomoko

AU - Amamoto, Toshiaki

AU - Watanabe, Kazuhito

AU - Omiecinski, Curtis John

AU - Aramaki, Hironori

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