Canonical transient receptor potential channels in disease

targets for novel drug therapy?

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

The canonical transient receptor potential (TRPC) channels constitute one of the three major families within the large transient receptor potential (TRP) superfamily. TRPC channels are the closest mammalian homologues of Drosophila TRP, the light-activated channel in Drosophila photoreceptor cells. All TRPC channels (TRPC1-7) are activated via phospholipase-C-coupled receptors and were, therefore, proposed to encode elusive native receptor-activated cation channels in many cell types. A physiological role has been established for all of the known TRPC channels, including the control of vascular tone (TRPC1, TRPC4 and TRPC6) or lymphocyte activation, which is essential for immune competence (TRPC1 and TRPC3). The emergence of TRPC channels in controlling a variety of biological functions offers new and promising targets for drug development.

Original languageEnglish (US)
Pages (from-to)924-930
Number of pages7
JournalDrug Discovery Today
Volume11
Issue number19-20
DOIs
StatePublished - Oct 1 2006

Fingerprint

Transient Receptor Potential Channels
Drosophila
Drug Therapy
Photoreceptor Cells
Type C Phospholipases
Lymphocyte Activation
Mental Competency
Blood Vessels
Cations
Light
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmacology

Cite this

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title = "Canonical transient receptor potential channels in disease: targets for novel drug therapy?",
abstract = "The canonical transient receptor potential (TRPC) channels constitute one of the three major families within the large transient receptor potential (TRP) superfamily. TRPC channels are the closest mammalian homologues of Drosophila TRP, the light-activated channel in Drosophila photoreceptor cells. All TRPC channels (TRPC1-7) are activated via phospholipase-C-coupled receptors and were, therefore, proposed to encode elusive native receptor-activated cation channels in many cell types. A physiological role has been established for all of the known TRPC channels, including the control of vascular tone (TRPC1, TRPC4 and TRPC6) or lymphocyte activation, which is essential for immune competence (TRPC1 and TRPC3). The emergence of TRPC channels in controlling a variety of biological functions offers new and promising targets for drug development.",
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Canonical transient receptor potential channels in disease : targets for novel drug therapy? / Trebak, Mohamed.

In: Drug Discovery Today, Vol. 11, No. 19-20, 01.10.2006, p. 924-930.

Research output: Contribution to journalReview article

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AB - The canonical transient receptor potential (TRPC) channels constitute one of the three major families within the large transient receptor potential (TRP) superfamily. TRPC channels are the closest mammalian homologues of Drosophila TRP, the light-activated channel in Drosophila photoreceptor cells. All TRPC channels (TRPC1-7) are activated via phospholipase-C-coupled receptors and were, therefore, proposed to encode elusive native receptor-activated cation channels in many cell types. A physiological role has been established for all of the known TRPC channels, including the control of vascular tone (TRPC1, TRPC4 and TRPC6) or lymphocyte activation, which is essential for immune competence (TRPC1 and TRPC3). The emergence of TRPC channels in controlling a variety of biological functions offers new and promising targets for drug development.

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