It remains unclear if surveillance of renal cell carcinoma (RCC) affords a survival benefit. Using 737 post-nephrectomy patients with M0 RCC, we examined whether detecting asymptomatic versus symptomatic recurrences influences mortality. Multivariable analysis showed that symptomatic recurrences were associated with a 3-fold increased risk of both overall and disease-specific mortality. These findings support that RCC surveillance provides beneficial patient outcomes.
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