CAR1, a TNFR-related protein, is a cellular receptor for cytopathic avian leukosis-sarcoma viruses and mediates apoptosis

Jürgen Brojatsch, John Naughton, Melissa M. Rolls, Kurt Zingler, John A.T. Young

Research output: Contribution to journalArticle

212 Scopus citations

Abstract

Vital envelope (Env)-receptor interactions have been implicated in the cell death associated with infection by subgroups B and D avian leukosis- sarcoma viruses (ALVs). A chicken protein, CAR1, was identified that permitted infection of mammalian cells by these viral subgroups. CAR1 bound to a viral Env fusion protein, comprising an ALV-B surface Env protein and the Fc region of an immunoglobulin, indicating that it is a specific viral receptor. CAR1 contains two extracellular cysteine-rich domains characteristic of the TNFR family and a cytoplasmic region strikingly similar to the death domain of TNFR1 and Fas, implicating this receptor in cell killing. Chicken embryo fibroblasts susceptible to ALV-B infection and transfected quail QT6 cells expressing CAR1 underwent apoptosis in response to the Env-Ig fusion protein, demonstrating that this cytopathic ALV receptor can mediate cell death.

Original languageEnglish (US)
Pages (from-to)845-855
Number of pages11
JournalCell
Volume87
Issue number5
DOIs
StatePublished - Nov 29 1996

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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