Carbon-nanotube reinforced vascular conduits

Farzaneh Dolati, Yin Yu, Yahui Zhang, Ibrahim Tarik Ozbolat

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cardiovascular diseases have remained one of the leading causes of death during the past decade, however fewer progress have been made in engineering small diameter vascular grafts. In this paper, vascular conduits were fabricated through an extrusion based bioprinting system. The generation of vascular conduits with natural polymer such as alginate needs to have improved mechanical properties in order to biomimic the natural blood vessel. Carbon nanotube (CNT) is one of the best candidates for this goal because it is known as the strongest material and possesses a simple structure. In this work, multi-wall carbon nanotubes (MWCNTs) were dispersed homogenously in alginate and printed using an extrusion-based system. The effects of using MWCNT as a reinforcement agent were investigated in mechanical, swelling and degradation tests. In vitro evaluation of printed conduits encapsulated in human umbilical vein smooth muscle cells (HUVSMCs) was performed to characterize the effects of CNT reinforcement on the biological performance of the conduits. Cell viability and tissue histology studies were conducted to explore effects of MWCNT on short term biocompatibility as well as long-term tissue formation.

Original languageEnglish (US)
Title of host publicationIIE Annual Conference and Expo 2014
PublisherInstitute of Industrial Engineers
Pages1-10
Number of pages10
ISBN (Electronic)9780983762430
StatePublished - Jan 1 2014
EventIIE Annual Conference and Expo 2014 - Montreal, Canada
Duration: May 31 2014Jun 3 2014

Publication series

NameIIE Annual Conference and Expo 2014

Other

OtherIIE Annual Conference and Expo 2014
CountryCanada
CityMontreal
Period5/31/146/3/14

All Science Journal Classification (ASJC) codes

  • Industrial and Manufacturing Engineering
  • Control and Systems Engineering

Fingerprint Dive into the research topics of 'Carbon-nanotube reinforced vascular conduits'. Together they form a unique fingerprint.

Cite this