Carbon-sulfur bond cleavage and reduction of thiols and dithioethers under oxidative conditions

Joseph E. Remias, Laurie E. Grove, Ayusman Sen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The reaction with hydrogen peroxide serves to cleave the carbon-sulfur bond and generate formally reduced products from certain thiols and dithioethers. The peroxide can be generated in situ from dioxygen using a supported palladium catalyst in the presence of a coreductant, either carbon monoxide or dihydrogen. The use of in situ generated oxidant provides a significant selectivity advantage compared to using a hydrogen peroxide solution. The reaction to form the reduced products is unique to compounds with a carboxylic group a to the carbon-sulfur bond.

Original languageEnglish (US)
Pages (from-to)3067-3070
Number of pages4
JournalDalton Transactions
Issue number15
DOIs
StatePublished - Aug 7 2003

All Science Journal Classification (ASJC) codes

  • Inorganic Chemistry

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