Carbonic anhydrases of anaerobic microbes

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Carbonic anhydrases (CAs) catalyze the reversible hydration of carbon dioxide to bicarbonate and are abundantly distributed in prokaryotes and eukaryotes. There are five classes (α,β,γ,δ,ζ) with no significant sequence or structural identity among them, a remarkable example of convergent evolution. The β and γ classes predominate in anaerobic microbes, living without O2, that comprise a substantial portion of the living protoplasm on Earth. Anaerobes reside in the lower intestinal tract of humans, one of many O2-free environments on Earth, where they convert complex biomass to methane and CO2 contributing an essential link in the global carbon cycle. Carbon dioxide is a universal metabolite of anaerobes necessitating CA for a diversity of proposed functions.

Original languageEnglish (US)
Pages (from-to)1392-1395
Number of pages4
JournalBioorganic and Medicinal Chemistry
Volume21
Issue number6
DOIs
StatePublished - Mar 15 2013

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Carbonic Anhydrases
Carbon Dioxide
Earth (planet)
Carbon Cycle
Methane
Bicarbonates
Metabolites
Eukaryota
Hydration
Biomass
Cytoplasm
Carbon

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

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Carbonic anhydrases of anaerobic microbes. / Ferry, James Gregory.

In: Bioorganic and Medicinal Chemistry, Vol. 21, No. 6, 15.03.2013, p. 1392-1395.

Research output: Contribution to journalArticle

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