Detailed syntheses of carbovir-related cis-[2-(9H-Purin-9-yl)-3- cyclopentene]-1-methanols and phosphonates of selected analogues are presented. Our interest in this chemistry stems from antiviral activity shown by closely related compounds. Access to the key β-lactam was achieved by the reaction of monocyclopentadiene with chlorosulfonyl isocyanate at -78°C rather than at the reported1 ambient temperature, where only the less ring-strained and more stable γ-lactam is formed.
|Original language||English (US)|
|Number of pages||13|
|Journal||Phosphorus, Sulfur and Silicon and the Related Elements|
|State||Published - Apr 2007|
All Science Journal Classification (ASJC) codes
- Organic Chemistry
- Inorganic Chemistry