Carbovir-related compounds and phosphonate analogues

Phuong T. Pham, Robert Vince

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Detailed syntheses of carbovir-related cis-[2-(9H-Purin-9-yl)-3- cyclopentene]-1-methanols and phosphonates of selected analogues are presented. Our interest in this chemistry stems from antiviral activity shown by closely related compounds. Access to the key β-lactam was achieved by the reaction of monocyclopentadiene with chlorosulfonyl isocyanate at -78°C rather than at the reported1 ambient temperature, where only the less ring-strained and more stable γ-lactam is formed.

Original languageEnglish (US)
Pages (from-to)779-791
Number of pages13
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Volume182
Issue number4
DOIs
StatePublished - Apr 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

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