Carboxymethyldextran Lactone: A Preactivated Polymer for Amine Conjugations

Ned D. Heindel, Michael A. Kauffman, Eric K. Akyea, Stephanie A. Engel, Michael F. Frey, C. Jeffrey Lacey, Roger A. Egolf

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The linking of amino haptens to carboxymethyldextran (CMD) requires carboxyl activation, for example, via carbodiimides. We have discovered that substantial N-acylurea, derived from these carbodiimides, can be trapped on the CMD backbone. As an alternative, CMD can be conveniently lactonized by heating in inert solvents, and this carboxymethyldextran lactone (CDL) can be employed directly for amine conjugation.

Original languageEnglish (US)
Pages (from-to)98-100
Number of pages3
JournalBioconjugate Chemistry
Volume5
Issue number1
DOIs
StatePublished - Jan 1 1994

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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